ID   A0A3B0JK70_DROGU        Unreviewed;       956 AA.
AC   A0A3B0JK70;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Blast:RNA exonuclease 1 homolog {ECO:0000313|EMBL:SPP80722.1};
GN   ORFNames=DGUA_6G005639 {ECO:0000313|EMBL:SPP80722.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP80722.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; OUUW01000005; SPP80722.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3B0JK70; -.
DR   STRING; 7266.A0A3B0JK70; -.
DR   OMA; PGGWETQ; -.
DR   OrthoDB; 5479236at2759; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR   CDD; cd06145; REX1_like; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR034922; REX1-like_exo.
DR   InterPro; IPR031736; REXO1-like_dom.
DR   InterPro; IPR047021; REXO1/3/4-like.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR12801:SF115; RNA EXONUCLEASE 5; 1.
DR   PANTHER; PTHR12801; RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED; 1.
DR   Pfam; PF15870; EloA-BP1; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:SPP80722.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:SPP80722.1};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:SPP80722.1}.
FT   DOMAIN          797..956
FT                   /note="Exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00479"
FT   REGION          82..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          133..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          420..454
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        150..214
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..249
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        250..292
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..319
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   956 AA;  106337 MW;  1114B91CD4D6B401 CRC64;
     MLPSTGLFKD FPCPYYDSEI DGVACKRPFC HFKHAKKDDV DAAPPAEPVP EYKPAQPKLL
     TLPLPEMTMY ASKKKKANLE YHPDKPALNA SPAKKNPEAA AGGAPAYVPA QVASTNGASG
     DWEADLENEI DEQLQIEVDE PSTVVVVNDK VGAKEEDLKE GELDDAPKSD KETSGSSESL
     KPKHKSSRVR DREDKEKDRK SSHKDKDRSK ERHKSSSSSS RHKSSSSSSS KNKSSSSDKH
     RDEKSSSSSS SRHKSSSSSS SSKRHHSSSS SAGRSSSSKS SKSSTSKASS EPSEPQTEKE
     TAKSTTKTNA HSDHESDIDY EMDNSEGEIL RQCEMIFDQL ETQFANIHNV EQTPENNLKR
     KAPSPDIDAL TEAATAALQK RRVAHENADK CRAPLPATVQ KPNHIRNAMQ AIFDRRTELR
     RQEKQRADAA SEELRQAQER VRVAQEELRQ AQVKSQLTPL IPRSALTAPV RSARSIAPVA
     NIVAIARAKK KIQELQAEKK PAFTPAQSFK GAGRMAHKPT VALDKTAPVV SDASAQKPPV
     LEPQSSKISY NIRMQYYEMM VKQCTTIYPQ LADAWERAQV EELAAFKKCN TTAIYKNSCL
     LAINKLRKEA IEAGNRPSVA NKCVSHEMML GGKRALTTSW SMEKKDKLTS MGNGEPFDAL
     DVVKAYEMVF DLRLTDEQLV ENGYPRPGTK RGTAVIRACR PNRRPNETER YCSRCGKVFN
     LNIYESRGTD MCNYHPKSTG YRRGFADNQH RCCQQPAGTP GCTYGNYHVS DYYDPDKLTC
     FVKTIERGED LVPTKKDIFA LDCEMCYTTH GIELTRVTVV DVNSRTVYDA LVKPDNLIVD
     YNTTYSGITE AMLAKESRTL RDVQAVLMSM FHAKTILVGH SLESDLKALK IIHDVVVDTS
     VLFPHKMGPP KKRALKTLCI ENLKRIIQEN EAGHDSAEDA EVCIQLIKYY LRNKIS
//