ID A0A3B0JKM2_DROGU Unreviewed; 1150 AA.
AC A0A3B0JKM2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Blast:Zinc finger protein 1 {ECO:0000313|EMBL:SPP80872.1};
GN ORFNames=DGUA_6G005827 {ECO:0000313|EMBL:SPP80872.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP80872.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR EMBL; OUUW01000005; SPP80872.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B0JKM2; -.
DR STRING; 7266.A0A3B0JKM2; -.
DR OMA; NGAGKMS; -.
DR OrthoDB; 4266655at2759; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24403:SF67; ENHANCER OF VARIEGATION 3-9-RELATED; 1.
DR PANTHER; PTHR24403; ZINC FINGER PROTEIN; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 75..103
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 316..339
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 352..374
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 383..410
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 411..442
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 676..700
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 767..827
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 1063..1090
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1091..1118
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1119..1147
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DNA_BIND 769..828
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 39..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..676
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..757
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1034
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1150 AA; 127590 MW; 52375AF734E2F754 CRC64;
MLSCLAPSST RFGQEDNSII QQSMPSSTAF TMQFPSLASS LHHHQAPHSK PSNGSGVGSQ
EQHAQPGVSV DDFLVKCTQC HKRFTEFQSL SEHIASEHPH DKLNFEASRG SSGAVQPESD
AEDEQSNLSG SRYAKSPATN TTTHANPSNN NNSDLAKNHN NNNNNSNSSK LSPMCSPGSG
GPAADLFAHL SHGTPPQLPP HLHAQFMAAA ALAMQSARSV SSSASSPNSH HHQQQSHHHQ
QQQQHHQQQH QHLLQQQQQS QQQQQQQQMA MQQLLPPQLP GSNSSVGSNS AYDLDLSAPR
STSSPGSTTG DLSGAYPCMQ CTAAFSSREQ LEQHELLHSP TGGQPTAQNV SQTCRICHKA
FANVYRLQRH MISHDESALL RKFKCKECDK AFKFKHHLKE HVRIHSGEKP FGCDNCGKRF
SHSGSFSSHM TSKKCISMGL KLNNNRALLK RLEKSPGSGP RRSPSDLQGP KNGAGKMSDQ
QSLPPLPNPM IYFAGEAQAQ AAAANGAPPP FYPNYMNAAL LAFPNPFMAA ALDPRVHPYS
IQRLLELTAA GQQQQQQQQQ QREEREEREQ HEEPATPEEP KLVMDIDEAE AKERLVPQAS
PQTMPEEIEP VVAVATTPIK QETSREPTPL PESAPPSPKS FKQEQEEPRS LEEDQPMEST
QPEATASSPN NTPVELRCSR CDKQFNHHTE LVQHEKVLCG LIKEELEQHY HQQQHQQQQH
QQLQQHEQLQ HQQQQASFAL PSASEDDDEE EERENDNDAE QRPDSNERKV RVRTAINEEQ
QQQLKQHYAL NARPSRDEFR MIAARLQLDP RVVQVWFQNN RSRERKMQSY ASVHTTAPAT
NEVPTTPVSS RPTTEDQPLD LSVKRDSLTP KSDHSAVYGL PQQQAAGQPA PADFQEAINL
SRKFSSSASM SPASLSPSSG ASLQQSSAAA AAAAAALWPF GGPPPSPPSQ HEATSAQHCS
TPRGGQAFPG LQYMLPMQRL PMEALFQMRP GGEYAPNPLM NSIKMPDFRG TSLSPGGSEK
RSWRDDDSRI SHEDDFGNGL MPPKPRRGKA ETHGHAGDPD LPFVCDQCDK AFAKQSSLAR
HKYEHSGQRP YQCMDCPKAF KHKHHLTEHK RLHSGEKPFQ CSKCLKRFSH SGSYSQHMNH
RYSYCKPYRE
//
