ID   A0A3B0JL01_DROGU        Unreviewed;      1192 AA.
AC   A0A3B0JL01;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=Blast:Patched domain-containing protein 3 {ECO:0000313|EMBL:SPP73321.1};
GN   ORFNames=DGUA_6G000778 {ECO:0000313|EMBL:SPP73321.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP73321.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; OUUW01000001; SPP73321.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3B0JL01; -.
DR   STRING; 7266.A0A3B0JL01; -.
DR   OMA; MWHITFF; -.
DR   OrthoDB; 2876883at2759; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   PANTHER; PTHR10796:SF92; PATCHED-RELATED, ISOFORM A; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        28..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        270..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        303..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        328..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        405..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        499..520
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        705..725
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        732..752
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        758..780
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        801..827
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        833..857
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          270..427
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          922..968
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1013..1192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        930..949
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1013..1048
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1052..1066
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1115..1144
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1192 AA;  135566 MW;  D6566028FACF01D5 CRC64;
     MACGISCVDK TLNKSFYHLG IKIAKHPGYF IIIPVLLTLL CMTGYQQLKY QIDPEYLFSP
     IAGEGKTERA VVEQYFKVNY THRFNVGRIT RPGRFGRVIV ITKDGDENMI RREVFQELRT
     LDNIIQNASS TYDGDTYTYK DNCARWENEC FENDILNLDA LMDDLEAGQL NLTFPFMFNP
     VTWDAHLFPV FFGGTKLTED NYVISVPAIQ LVYFVTADNK RQDAKGAEWE ETFLRVVGQA
     EESGLFKHIS VSYFASRTLD HELEKNTKTV VPYFSSTFLL MGLFSIITCM MGDAVRSKPF
     LGLMGNVSAI MATLAAFGLA MYCGIEFIGI NLAAPFLMIG IGIDDTFVML AAWRRTKAKM
     PVAERMGHMM SEAAVSITIT SVTDFISFLI GIISPFRSVR IFCTYSGFAV CFTFLWHITF
     FAACMAISGY RERKNLHSIF GCRVQPMSVA IKEKRNFLYK ALMAGGIDGA DPDNPIDNKD
     HMLMAFFKDK MSTVINNKWC KIIIILAFAT YLAGACYGIT QIKEGLERRK LSREDSYSVE
     FFDREDDYYR EFPYRMQVII AGPLNYSDPL VQQQVENLTS TLEHTSYVTS KRYTESWLRS
     FLSFLERNNE LLNATIDDEQ SFIDAVKEHW LFPGNPFSLD VRFNDDETQI IASRFLIQAV
     NITDTNHEKE MVRDLRKICR DSPLNASIFH PYFVFFDQFE LVRPVSLQAM IIGAIIMMII
     SFIFIPNILC SLWVAFSVIS IELGVAGYMA LWDVNLDSIS MINLIMCIGF SVDFTAHICY
     TYMSSKKRSP KARVREALHS LGLPIIQGSS STILGIVALL LAQSYIFLVF FKMVFLVVFF
     GAMHGLFLLP VLLSLFGPGS CLTWTGRDDG SEDEIDDSLD ERKQEKPFSQ SYYMQYPTMG
     INGPYGSKGF LGAPYKAYGV DEKDQGLGTS GEDSSESSSS RSQRRQQLAN AAAEEEAATQ
     DPRRRYEEGW RRSSYQNIYG PNASIIAGHV QAQFQAQPDL YGQQVSAAEW RQRLDAHEQQ
     QQQRSRQRRS PYENYDMDMQ RARRNSHGDV IDIMQGTPNS SVDERLRRPY TSQDRAMLSG
     GSGDEGSYRQ QPGRDSPPTA ALPPLGHASS AKRYHRRRSS EDSTRHHQRW PANIEERRAR
     RTQSPALRQP ETAPPPSFAY RSSSHHNLYQ PHKSGHKATK QPPTYQYGDY YH
//