ID A0A3B0JLK0_DROGU Unreviewed; 628 AA.
AC A0A3B0JLK0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 28-JUN-2023, entry version 17.
DE SubName: Full=Blast:Signal transducing adapter molecule 1 {ECO:0000313|EMBL:SPP81733.1};
GN ORFNames=DGUA_6G013463 {ECO:0000313|EMBL:SPP81733.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP81733.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the STAM family.
CC {ECO:0000256|ARBA:ARBA00009666}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; OUUW01000006; SPP81733.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B0JLK0; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd21388; GAT_STAM; 1.
DR CDD; cd11820; SH3_STAM; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR PANTHER; PTHR45929:SF3; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF02809; UIM; 1.
DR Pfam; PF00790; VHS; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00726; UIM; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1..94
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 190..249
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 105..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..563
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 68383 MW; 9DED98EAC0645519 CRC64;
MRRMGHNDPH VVMQAITLLD ACSNNCGKPF HLEVASRDFE TEFRRLLTRA EPKVSLKMRQ
VLKNWAENDY KNDRELDLIP ALYTKLRLEG YDFKNLSEKS SKTAAEKAAS LPKDPNVVSS
QQEEDDIAKA IELSLKEGKS SPKAVSGSAP SAANTSAYPS LYPSFGGGGA TSSSTTSNEA
NSTQNQAPAA EPRKVRALYD FEAAEENELT FFAGEIIHVM DDSDPNWWKG FNQRGEGLFP
SNFVTADLSV DPERLDINQQ HKTGAAPKDV NSATTSQQKT DPAAAAAAAA ASAQPVEIDE
AKIDRLLHLL HEANPEDPSQ DSDEMLRLEQ EVHQMGPLID AELERVDRKH AQLTQLSSDL
VDAINLYHGL MRDDRAVAGQ FAAAAAGFMP GLAGFPGAAL YGAPGYPSAG GFPPHQNYPG
MHSLPYAPGP NIPTNAPPPT TAPAGYLEQG QVPLTYQNGH APQMNSLPPH LPHLNPAVSV
PQPLYNAHAP PVSAQQQQQQ APPPQQQQQP SYQQQQPPFA QVPPANTQMQ QQQSQPPPQA
YMQAGPPQGY QPGPTPQQPP SHLYAPNGSP AVNQQSYVPQ QQQQHQLTPQ EQYSQMHQQM
ASQPAAAPGY HMQNDAVKNN IPIYQQQW
//
