ID A0A3B0JM13_DROGU Unreviewed; 626 AA.
AC A0A3B0JM13;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Blast:Sodium/potassium/calcium exchanger 6, mitochondrial {ECO:0000313|EMBL:SPP74316.1};
GN ORFNames=DGUA_6G001937 {ECO:0000313|EMBL:SPP74316.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP74316.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; OUUW01000001; SPP74316.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B0JM13; -.
DR STRING; 7266.A0A3B0JM13; -.
DR OMA; YPKMAFA; -.
DR OrthoDB; 5482417at2759; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR12266:SF0; MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN; 1.
DR PANTHER; PTHR12266; NA+/CA2+ K+ INDEPENDENT EXCHANGER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 75..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..221
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 457..603
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
SQ SEQUENCE 626 AA; 70623 MW; 4F95DB079E793110 CRC64;
MSDQQDGAEQ EPNAMDREFD EFWDKVSCYV VANFPYDERC DFVLNATTCI TDTIFVPYMR
MLACDLKCRN QFQELVYLTL FVAFCLQLLM CLTHVVDMYY SPALKVVSQL LHMNEHLAGV
TLMAFANTSP DLAANLAAIK QEVPVFANSL AMALFVSMFT GGMICYISPF KMNTHGTVRD
ILFFMLGVAL LEYVMVSHGA VTMNECFLLV MVYISYIVVN ILDVYLMRKA MITLEHQMAE
LQDQPFTPEV RRKLEKLQEQ YSEYAEDATV EILERPDSKV RGSIVNPLSD KLSFATKRAS
RVRLSVNPQA TRSVFYNLTA GRNHGLLMDF FKTLNPIDVA EWRENNMFGR AFQLAMAPAK
FLCAAYIPLV DHEMEKHGWS KLLNCIHTFL NPAITIVVSM ALLSSDKKKL WYWQLGNTYI
YGLYSCAITV PVALVVFAHS RSDVPPIYHW LYTIMNLTGS TFLIFVCASE IDKLLGVVGN
ILNIEEDFMG VTVNAITQAL GDLVANTAMA YQGYEKMAYA AAIGGPFFNV LLATGAVMYA
KLNIGMEVTI QEQTGQYGTN AYIFLNLGLF ATLLWTSTLD FFARRSMGVF SMGIYFLFLV
FALLTHQNVI HSFAHDPTVE PSLYLD
//