ID A0A3B0JNA5_DROGU Unreviewed; 694 AA.
AC A0A3B0JNA5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Blast:Protein enabled {ECO:0000313|EMBL:SPP72688.1};
GN ORFNames=DGUA_6G000047 {ECO:0000313|EMBL:SPP72688.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP72688.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the Ena/VASP family.
CC {ECO:0000256|ARBA:ARBA00009785}.
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DR EMBL; OUUW01000001; SPP72688.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B0JNA5; -.
DR STRING; 7266.A0A3B0JNA5; -.
DR OMA; YQQMVQV; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR CDD; cd01207; EVH1_Ena_VASP-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR038023; VASP_sf.
DR InterPro; IPR014885; VASP_tetra.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR11202:SF22; PROTEIN ENABLED; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF08776; VASP_tetra; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF118370; Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain; 1.
DR PROSITE; PS50229; WH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 1..111
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT REGION 154..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..235
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..391
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..494
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 694 AA; 73702 MW; E480404DC8D9665F CRC64;
MTEQSIIGAR ASVMVYDDNQ KKWVPSGSSS GLSKVQIYHH QQNNTFRVVG RKLQDHEVVI
NCSILKGLKY NQATATFHQW RDSKFVYGLN FSSQNDAENF ARAMMHALEV LSGRVANNPG
GQPTNGNGYE EDMGYRTMTS EDAAILRQNN GIAGHITPSA QTPTSQTNQN NIPQSPPTPQ
GHHRTSRNSL SAPPAPQPQQ QQQQQQMAPP GPHYGPPTGN GPTPNGLPAQ VNPQIPPAPG
QALQQPQTQQ QQQQPYQQQP QQPLYAAQQQ QMVQAGYPPA QYQQPHYVLS NSNPNLNMHQ
YPTQPPQQTL PQQQQQQQPQ PPHQNGGGPI YVVSQPGHGH GHIPSSASAN SVVYASQQQM
VQQQQPPQAP AMPGPGYGPP QAHPQPPPQQ QQQAENPYGQ VPIPPPMNPS QSQTPLNRMS
SQGGGQPAAP APPPPPPTFG GAPPAPPQMF NGAPPPPQPP APPAPPAMGG PPAPGVSGGP
GAPPPPPPPP GMGGALKKDD PQADLMGSLA SQLQQFKLKK NKSTTSAPEN SGSSTSSGGS
GNYGTIGRSS NGMASMMDEM AKTLARRRAQ AEKKEPDPEP EVKQRPWEKS NTLPHKLGGG
AGSGSGTNGP NGSSGGAGSN TTNSGGESPR PMRKRFGSAS EETILKVNGD GLSLALSNGD
LDTLKAEIVR EMRLEIQKVK NEIIDAIKSE FNRR
//
