ID A0A3B0JNT3_DROGU Unreviewed; 2518 AA.
AC A0A3B0JNT3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=DGUA_6G000272 {ECO:0000313|EMBL:SPP72878.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP72878.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR EMBL; OUUW01000001; SPP72878.1; -; Genomic_DNA.
DR STRING; 7266.A0A3B0JNT3; -.
DR OMA; SMYIGWC; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SPP72878.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1506..2066
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2185..2509
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2486..2518
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2518 AA; 287659 MW; F678208857691590 CRC64;
MANHRKEMWK LLYNLVNRNE GNLSQAYTVI EDILCQEPSL ISCSLVRELN NKFQDTFLLW
LLNKLAKCLG KGADGSQCLN LQRKIISSCC SNHPKLYERL VKAYVEALQE IHVQLSALDY
SEGSARNNKT LTLRIFTCDA APLLEFDPQC TFEDIQLPLD TADAYAKSLI AILQHAHHIG
DATHGDIFSG SLQQALLILK ECDMDTKLAS LDYCHGVLKS QSSQSWLSNP DVAHYAQLIL
EAITMMWSMA GKWLEMVCMS QQELKRLDVC TRQLLLVLQL RGREALHQSY LLLNEILGLS
KNLQIDEGLL QCLSHYVQGV LDDSSATSME QLLLLKELVM SHWRSHPAQL LPLLALLAGK
QPEMRSSIVQ ALTLSLSQLL PQNQHQTDEW REMVAILRAF KQLEQLILWQ NQQELMEGKD
KLDSAMLATF PLLYELPSEM DINWNQLSTH LVSQESRHRS SAEELQMYLE ICALLMQIAC
IRHSLKPQMQ QQLLAILQRH LSEGLVHLCA VRLETPSSAH TQLQSFYAQQ YMSLIEWSEE
TFCQYLPQLY LSGFLKPEQL LKALPCIGHP SARSKVIRLL LCFQLSAFKV EDRVELYCPQ
CRPLPDQLPG LFLGKSKPNA ASSLDLSSAT LELIVKDLLF QEDSSLIAHH LDLLGVSPEL
VLRLLKQGLQ EVSEKSFSLL VPALSSKSAD FMQQLGHFML AAIKQMLVKP LAEQSKSEQR
AVLRIIISCA HSDIDEIWLF HWFKMTFFFL VHTHSLVAQE AVMTATEMCA RHGLQTVNLW
NWYKRDALDL AVRLALTAYL TDGVRFTRSL RALTKMLGFS CVQEFTCKYH RLLTAMVLPH
CIVEPRCKGV LVLIAKQLRK PIATLFTISF LRLYTHVYLT EEPELANSCI QLVVTCTQSS
LQELMNADVK QTVAELLIYF NRNPTFVMKS FQSLLQLSVG NEQPLSSQSA NAEFATFIAE
RFLGVITYFE SCLSEPSFEK PLKEETLYSL GQIMRFVGAK HVTQFRFKIM AMLSFVHTLQ
EPRLQRICLK IWHIFLHVVN VQELGPSLGR IVATLQPLLQ DGESVNQVND LYEFVILRNA
SMLGNFITDL YFLERMENVS PNIRECIKRH TSHLDLAGEE AHSPPQLLEQ LRFLHKQIID
ECLQVRVYGL QHLGELFGRR RTQLNRMILN ELPLEPLLEQ IVNVLMAGCQ HDDRQLQLAS
AKCLGELGAF DASYLLSNYN FDSPQPLPLT VMSDDFAVLA LTALCRGYQF QQKTKHVDSF
SLAIQETLAV CGISPKEQKK VRLWQSLPAR MRQVMEPLLQ SCYTSCQRAS NCQQQPIFGS
HYSNNSYEEW AFVWASRLID YIQNEDTRHL LSSYKPCIKR DGNMLSTFCP YILLHALLEC
NAEQGQHMLE EFLAVLQANE ESASSSSKAQ QELGAVKENA FKMFESKKYT AGVKQPAGSV
LERKEDSSHV PRLAGKLCAE LLDFLQRWLR EWQRMHGRST AGRPPQDVDA NYGKIHEFLG
RIPKLLVSRA SYNCGEYARA LSYLESYLEE GEDKSKRIRE QFTFLVEVYG KLLDSDSVEG
AVQARSYDMS VTQDILVNRL VERQQDMITC YEQLLSSTDN LQPEHIRAMI DAYLMDTPKT
AQLIADGLWQ RLSDQYTEQC FSECKAELLW RLGSYDELDD WKSSSNWPAQ CAQGCLALRQ
PLTTRPQFDS LLDGMRGSVL EQLRSCSAVQ QHSYANAYDA VLKLHLVHEL QCSQQLVEQL
QQESAEERQE QLMREYFEDW HARLQVIQPQ VRVQEPINSF RRNLLSELQQ RLADRRHLQP
HLQTELASLW LNSAQINRNA GQLQRAQLYL LKAADYKPSG LFLERARLLW QKGDQVMAMN
YLEEQLSIIR GSCQGNAKQL SLEQRHLYFG GKYLQAVYNA ESMHLCADAI LRYFHEAIAV
HRQSEGCHVQ LAQFLEKMRE AGSSKSGATA SHESDELLLQ IMLNYAKSLR YGREHVYQSM
PRLISLWLDT GESSTNPELV KKMNDLLSNC CTALPTPIFY TVFSQMLSRL CHPKPEVFSV
LRNVIIRLVE DYPQQSLWML LPHFKSATAN RIKRCKLVLT DGRLQNAAFQ KLLHDFNSLT
ERLIELTNKD VALDRSYKLS ELDKRLPKLC SQPDFSSILL PFEKYMQPTM PLSLESTSAA
TLSPLAASGS PVNWFPYQQI YISGFLEQVT ILRSAAKPKK LTIRCSDGQE YDVMVKPKDD
LRRDARLMEF NGLVKRYLHQ DAPARQRRLH IRTYAVLPFN EECGLVEWLP NLSSYRSICM
ALYAQRGGVM SSRQLQQLAL PLTDPIEKKR DVFTKQLLPA HPPVFQVWLR QRFATPHSWY
EARHAYIRTV AVMSMVGYIL GLGDRHGENI LFDERNGDAV HVDFNCLFNQ GELLTYPEMV
PFRLTQNMIA AMGPLGVEGS YRKCCEITLR LLKQEAKTLM SMLRPFVYDV GAQSRNAAAT
TKITNDVQRI ADRLQGHVKR QQANSIPLST EGQVNFLIDE ATKLDNLAVM YIGWGAFL
//
