ID   A0A3B0JPC9_DROGU        Unreviewed;      1374 AA.
AC   A0A3B0JPC9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Blast:Protein disulfide-isomerase A5 {ECO:0000313|EMBL:SPP73028.1};
GN   ORFNames=DGUA_6G000433 {ECO:0000313|EMBL:SPP73028.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP73028.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; OUUW01000001; SPP73028.1; -; Genomic_DNA.
DR   STRING; 7266.A0A3B0JPC9; -.
DR   OMA; CTDHENC; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   CDD; cd02961; PDI_a_family; 4.
DR   CDD; cd02947; TRX_family; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 12.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR19991:SF2; GH08893P; 1.
DR   PANTHER; PTHR19991; L 2 01289; 1.
DR   Pfam; PF00085; Thioredoxin; 2.
DR   Pfam; PF13848; Thioredoxin_6; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 8.
DR   PROSITE; PS51352; THIOREDOXIN_2; 5.
PE   4: Predicted;
KW   Isomerase {ECO:0000313|EMBL:SPP73028.1};
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..1374
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017351795"
FT   TRANSMEM        1337..1357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          36..172
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   DOMAIN          329..492
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   DOMAIN          543..705
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   DOMAIN          896..1009
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   DOMAIN          1094..1242
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
SQ   SEQUENCE   1374 AA;  158989 MW;  8FF1CDF80EC0FD0F CRC64;
     MTFTRLKTVT LLVTCALLAL SFPGYVNCAN NGKKGSQPAA AAAPLEPEAV IEEVNAKQLE
     KLLADKDYVA VFWYARSCVT CDKVLAELEK IDDDTDSFGV DFVKINDKRL AKQYGIKNFP
     ALTYFREKEP IIYDGDLMDE EGVLDFLTSL EAMDLPDRIE EVNAKILQKI IEDTDFVAVL
     FYDKDQKKSQ KILAELENID DECDQNDIAF VKIDDDKEAK EWGIDEIPSI VLFERGIPHI
     YEGDLMKEDE LLGWLVHQKR YSEIPEVTDE MKDKLVENTE HLAVIFYDKD DKQDMRILNE
     LENIDDELEK EGIVIVRIDN AAEAKEYGLD HLPALIYFEN KIPALYEGDL MNEDEVLEWL
     LVQKKTATIE EVTDEILVNL INEHEYVVVF FTGPCEPGET CDHTLNALET IDDELDEAGI
     IFVTTEDTGV AKKYNVKTYP RLVFFRNRDP LHFTGDLDDE DEVLAWITDD ETLEIPGKIE
     EVNVKMLDKI LAENDHVVVF FYAEGDKKAQ KILNELENID DECEEKDIDF VKTSDDDIDK
     EYDLPGLPAL AFYRHKFRTI YTGDLMKEEE ILEWVIDLHE STADVIESVD RKTLQVLIND
     VEHLAVFFYD DECETCSDIL DELENIDDDT DKHGIQFVKS NDVKLAHEIG IFAFPALVYY
     ETGVPIMYDG NLDSNQEVFN WILEQKADQS IELIDREQLL EYIGTKDFLA VVFYKEDDPD
     SPRVLRHIEL IDDEASEYGI YIVKMHDKLM AKKYGFRNPP GLTYFRKGKY INYDGDIDDE
     EEVLDWLTSP ANMEMTDHIE QVNRKMFEKI RKNSDYVAVI FYSDECKQCP RVLAEVEHID
     DEADKAGIDF VKIDDKLMAK EYGVFALPAI VFFKPTSKEP VIYAGDLYEE EQILTWLITQ
     KDPSGDVIED LEGERLVHLI EESGSIAVYF YADGCEQCTK VLEELENIDD DCDKHGITFV
     KTRDFSVADG YGVHEYPALV YFEGGIPNVF EGELSEEEEV LQWLITQKTE DRIELITRQM
     LETMVEETQY LAVYFYKINC NICDQILEGL ELIDDECDVF GIHMVKIQDP QLAKRYSIKT
     FPALVYFRNG NPLLFEGDLQ NEQSVLEWLI DDDNRELADE IEEVNERMLD RLMAESTLLV
     VFFYDDDCAE CEEILEELEE IDGEADMFGI DFVKIASMEA AKKYEIVNIP SLVYYRKQVP
     VLYDGDMHQH DKVITWLTSQ DVFEIKNEIE EVNRKMLDKL LEENEFLSVF FYEHNHPDSI
     ASLEKLENID SETDNLDITF VKMADSRYAK KWGVTKLPAM VYFRRRFPSI YRGDLLSEDE
     VLEWLRKNRF RQPELNIFMY ALIALALAFV VYTAFLLQCF KPAPPPPVQH TKQS
//