ID A0A3B0JSD9_DROGU Unreviewed; 997 AA.
AC A0A3B0JSD9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Blast:Glycine receptor subunit alpha-4 {ECO:0000313|EMBL:SPP85034.1};
GN ORFNames=DGUA_6G014915 {ECO:0000313|EMBL:SPP85034.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP85034.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; OUUW01000009; SPP85034.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B0JSD9; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProt.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18987; LGIC_ECD_anion; 1.
DR CDD; cd19049; LGIC_TM_anion; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945:SF819; PH-SENSITIVE CHLORIDE CHANNEL 1, ISOFORM N; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:SPP85034.1};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 626..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 690..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 972..993
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 435..620
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 633..989
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..850
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 997 AA; 110531 MW; 316AB2410C1C9F88 CRC64;
MGCVFEAAKE QPNKKPQTRA TTHNKQLRRN QCGARREATT TTTGAGWATA DTVTQVIEGL
AGGTTTTTLR PAEDIKIKDN YQQNHKTQTQ THTEIAEIVV ETETQTETET ENAKHLKAGT
RVLLTIQQQH QQQPQKNPSQ VAHKDKDEDE NDELATTSGT TIVVDREAVP SAAGIDIVAT
TKQTQTLCPN CLGHSPEISR ERDRDRDEQQ LLRQHRRRRR LHTDAAAEAV WGRIRPGLGS
TAVVAATLAG ISTLSLHEML LHARAALATS LQWQEEQEQQ QQQEDNEEQE QDSRKQPLAY
QPWQDTFAAG ILPATMSAAI IANVSATAAA TSAAAYQYLG QHYKHYSQSF SFYAASSVIL
MLCYLTSTST AAATQSETGA LDKHPIFDES SSDKEILDLL LEKKRYDKRL LPPVNDEDFC
CGLQSPDMAT NQNPRRPHNR GTLTVNVNVL LLSLASPDES SLKYEVEFLL NQQWNDPRLQ
YGNKSHYDFL NALHHHDSIW TPDTYFIMHG DFKDPIIPMH FALRIFRNGT ITYAMRRHLI
LSCQGSLHIF PFDDPKCSFS MESISYEEAQ IKYVWKNDED TLRKSPSLTT LNAYLIKNQT
TACDQNSWRG NYSCLQVELT FTRDRAYYFT TVFIPGIILV TSSFITFWLE WNAVPARVMI
GVTTMLNFFT TSNGFRSTLP VVSNLTAMNV WDGVCMCFIY ASLLEFVCVN YVGRKRPLHN
VVYRPGENPV TQASAVATPS MSMAGTPAAS SSAATPGTPR TVEAVEEFFG GGMRWQEAHG
GIIGAAVQNI RARSIKRKAA RSPSTSTSPT AATEHIYEEP GVSGTAGPTK VKFKDDQKED
SQKEEQESIA SSLRRSVATS TPALVVRIEA ETQAEQDMEM LQLPQKPPRK KPSRSSSPAS
VYAESGAGGM ETGEKRRDAG APNEIVACTT CGGSNSPCTH SANNGCATET CFVQVRKKEP
PHPIRVAKTI DVIARITFPT AYAIFLVFFF VHYKGFS
//
