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Database: UniProt
Entry: A0A3B0JT11_DROGU
LinkDB: A0A3B0JT11_DROGU
Original site: A0A3B0JT11_DROGU 
ID   A0A3B0JT11_DROGU        Unreviewed;      3966 AA.
AC   A0A3B0JT11;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   28-JUN-2023, entry version 20.
DE   SubName: Full=Blast:DDB1-and CUL4-associated factor 8 {ECO:0000313|EMBL:SPP85254.1};
GN   ORFNames=DGUA_6G015161 {ECO:0000313|EMBL:SPP85254.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP85254.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   EMBL; OUUW01000009; SPP85254.1; -; Genomic_DNA.
DR   STRING; 7266.A0A3B0JT11; -.
DR   OrthoDB; 166463at2759; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703:SF30; DYNEIN AXONEMAL HEAVY CHAIN 12; 1.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          676..1102
FT                   /note="Dynein heavy chain linker"
FT                   /evidence="ECO:0000259|Pfam:PF08393"
FT   DOMAIN          1240..1565
FT                   /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT                   motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12774"
FT   DOMAIN          1737..1869
FT                   /note="Dynein heavy chain AAA 5 extension"
FT                   /evidence="ECO:0000259|Pfam:PF17852"
FT   DOMAIN          2089..2179
FT                   /note="Dynein heavy chain 3 AAA+ lid"
FT                   /evidence="ECO:0000259|Pfam:PF17857"
FT   DOMAIN          2250..2511
FT                   /note="Dynein heavy chain AAA module D4"
FT                   /evidence="ECO:0000259|Pfam:PF12780"
FT   DOMAIN          2533..2868
FT                   /note="Dynein heavy chain coiled coil stalk"
FT                   /evidence="ECO:0000259|Pfam:PF12777"
FT   DOMAIN          2898..3119
FT                   /note="Dynein heavy chain ATP-binding dynein motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12781"
FT   DOMAIN          3364..3477
FT                   /note="Dynein heavy chain region D6 P-loop"
FT                   /evidence="ECO:0000259|Pfam:PF03028"
FT   DOMAIN          3513..3652
FT                   /note="Dynein heavy chain AAA lid"
FT                   /evidence="ECO:0000259|Pfam:PF18198"
FT   DOMAIN          3660..3962
FT                   /note="Dynein heavy chain C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18199"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          2768..2816
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   3966 AA;  454174 MW;  AC19689AF5E9C4B5 CRC64;
     MYSRKLSRMH RPPSDTSKYD NEPYMKNPLL KFRISDVHER RHYQFLKQKA ADVKVRIARQ
     NWPPEPDIRP LPQSHYVDNL RREVRKIIVP PMLRKTEAKI LSFASERLRN RYPDLVDSYM
     RDVHEEYNRL MKIYSMKNIL RHPEFSDEDP SKFELPQADF HFKRPGRTAN YSAYLENRRK
     IGQKLLILQL PMRAVLSISV SDLPDVVCIF KYISATGAQQ QQMGLGGREA LSYKFYRKYI
     QNQLDKVNTF LRWTWYPKLV IVLRKMLRKR VMTPALWKRA WSGLEGLMNR ELNNMKMRTF
     IAMFRICSNP RTMPMFRMSL EWTEVSGELD TRPNLYSILR TFAEISTEIS MVGYRMESLQ
     PQVETLTSMA AYAKVNDYLK IEMNDNSLKD VIDKVQKIII ATYAEVTAYI DNFRNKYDAL
     FSWEERDALN NFLAEPHAFE EYFARIDVYY EFINLLRSEP AVEYFVMAVI HNEPAIQGLR
     NLAENLIAEI TVIIIREHIK AEEEICEEFE KIKYRALEIP KSTEELLESA DYMIHVKTVK
     LAELTDRIQY CLQVGTNIVE LTEMSKYHFD LTIKTINWIK DINEICEYNA SQQEQFKFLF
     EEHLQEVVKK LNSDIEEMLP KLAIIDDMSR PEKFRDSYII LQNFIDQLKT FDDYVAWINK
     EEKLFKVAQT EYPTLEVIKS FVYPFAEIMK CCIDWQRYLN VWQDGPFEYL EPKFVESTTD
     NYLKEFQKNQ KYYRVKIKQD LIDNPVCKFK GQTEDPDPAK HPVPLRLCTS MIQSIKDFTT
     GVFVVNIMCN PALRKRHWKE MSEIAGFDVT PDAGTTLRKI LNSGLDHILD QFEIISISAN
     KELQLWNALQ AMIKEWENKV FPTGPYKETG VTILNSLDDI QALLDDHILK TLTMRGSAFM
     KPCEEEVRAW YEKIMRVNET LDQWGKVQAN YLYLLPIFSS KDIVAQMPEE GRLFTIVEQT
     YSRNMGLVLR QPLVMETAPA SGLLESLQKA NELLEDISTG VSNYLEKKRL FFPRFFFLAN
     DEMLEILSET KDPLRVLPHL SKCFEGINSL EFDANKNVLA MISSDKEYIE FIEPVSTLAA
     GGSVEKWLIG VEDEMLKAVR NQNELSYGHY PKVKRHEWVL EWPQMTVLAI SQVFWAAKMH
     GCLRRSFGGN QTVMTNFFQE LSKELNDIVA LVRSPVISNL NRITIKSLIV IDVHAKDVTE
     ELIRLKISSE YDFQWLAQMR YYWEEEQTLV RIINATVPFA NEYLGNSDRL VITPLTDRCY
     RTLVGAYQLH LNGAPEGPAG TGKTETTKDL AKALAVQCKV FNCSDGLDYK AMGKFFKGLA
     SCGAWACFDE FNRIELEVLS VVAQQILLII QAVRANVSKF MFEGTELMLN PAVYVCITMN
     PGYAGRSELP DNLKVLFRSV AMMVPDYAMI GEISLYSYGF VDARKLAVKI VTTYRLCSEQ
     LSSQNHYDYG MRAVKTVLSA CGNIKKQYPD ELEDILLLRS LIDVNLPKFL SFDVPLFEGI
     ISDIFPGISL PHIDYSLFET EFKRVCKEEV LEPAPSFLTK VIQTYEMIIV RHGFMLVGEP
     LAGKSKTLQV LAKVMSALKI KAPDKSSYFQ HVLMGIMNPK SITMNQLYGS FDPISYEWTD
     GLVAKIFREF AMTPTPDRKW VIFDGPVDAV WIENMNTVLD DNKKLCLTSG EVITMSHEMS
     MIFEVMDLAQ ASPATVSRCG MIYMEPSTLG WRAFANSWLK KADPRWADAE GVEYVTAMLQ
     WLLPQCQTFV RRHCSQFVRS GEFNCMQTTF DLIDMLLDEA IEENPEDYQK YIVGYFQAAI
     LFALVWGVGG ILDTASRDKF DAFLRKIYDG EEAHPPEALG KMEVTPPVEG LIVEYVYVFK
     QRGTWRYWPE LAKRMDVEET KTGVIVPTVD TARYVHLLKM HVNHKKRMLL VGPTGTGKSV
     YVQNYLMNKL NQEEYETGFI TFTVMITANQ CQELLISKLQ KLKRGIYGPP KGMQSVLFVD
     DMNMPVKEVY GAQPPLELLR QYFDYGHVYD LKDASKLYIN DVLIVAACGL PGGSRQDVYA
     RFLNHFNVFS INTFSDDSMF RIFLNVALNG LRRSGHGQDV FVVTNQIVSA TQSIYKSVQS
     EIRATPAKSH YIFNLRDISR VVTGCTLVRK ESVNDKKILV RVWYHEAMRV FYDRLVDDTD
     RKWMFDKLNE CLKANFKDKV ENIFDKYCVQ VGDEQVFSME TANNVFFGVY FDEDSVPDER
     RYEEVPSVEV FLKVALDSLD DYNSTRRSKM DITLFTFALQ HLNRICRIIS IQGASALLIG
     LGGSGRQSLT KLATNMVQTS FFQPEITKNY GANDWHDDIK VILKEAGGMN KHTTFLMTEN
     QIKMELFLQD IDCLLNQGEV PNIFPIDEKQ EVLEMVRLAA QGGNRNIDVS PLQVFSFFVN
     RCKQKLHMVL SFSPIGDALR TRVRLYPSLV NCCTIDWYDS WPEEALQMIA KMSLVDVNVP
     SEEIKMAIVD TCQYFHTTAA RATRAFCQQS GRHIYQTNAS FIELIRSFQT LIDRKQSETM
     FAKMRYIGGL DTLANAAAAI SIMQRDLNAL QPKLVALAEA SRKMMLEINK ETLAASAAAE
     QVKRDEEVAS VQAVAAQVLK NECEKDLAKA IPVLEDALAA LNTLKPADIT LVKSMKNPPS
     VIKLVMAAVC VIKAIPADRV PDPASGKMVM DYWGPSKRLL GEMNFLPALK EFDKDNIPVE
     IMKRIRKEFI PNKDFDPKVV AKASSAAKGL CQWIIAMDMY DDVAKVVAPK KAKLAGAEKE
     YADTMSFLAE KRALAAALEE KVALLNIELD KANEEMKKTE EHAENCRNKL LRAEALIGGL
     GGEKSRWNKA ADDLQDLYDH LPGDVLLSCG IIAYLSAVNL QARTECVNDW FQKVTSLQIP
     CSKKYSITEV LGLEVTIQNW QLDGLPNDEF SSENAIIVSS SSRYSLFIDP QGQANNWLKN
     MERKNRLNCV KFNQGNYMRV IAEAMEYGTP VIIENVQEEL EVPLDPILMH QTFIQGGVKH
     ISLGESVVPL SPNFRLYMTC NLRNPHFLPE TFNKVTVINF ALTQNALMDQ LLSIVVAKER
     PDLQELRITL TTEAAANKGA LRDAENLILK TLSASEGDIL ENEAAIQILG ESKGLSKDIQ
     EKQEAAKETS AKIEAFRLNY KPVAVHSSIL YYSITDLPNI DPMYQFSLNW YINLYMYSID
     TANKSKDLPR RIKFLVDGFT KNLYNNVCRS IFEKDKLLFS FILTARVLLG TGQVEMRHLA
     HLVTNAKEST HMPPNPDPSW ITETVWLNVL RLEELKELRG IVDAFRRNLS AWQTIYDHAS
     PEVQPLPAPW HDKTTAFEKI IVLKALRPDS VFLAVRKFIA ITIGDQYVSP PEFDISKSYA
     DSTALTPLVF ILSPGADPLG SLLAFAEKMG QEETFQSISL GQGQGPIATA LIKSAQEMGY
     WVCLQNCHLA ASWMPALEYM WENMDTFNTV PNFRLWLTAY PTPQFPVTIL QNGVKMTNEP
     PTGLRENLMR SYNSEPINEY EFYAGCAKQD RAFTRLLYGI CFFHAVVQER RKYGPLGWNI
     AYGFNESDLQ ISVLQLSMLL NQYEHVPYDA ISYLTSECNY GGRVTDNWDR RAIVTILADF
     CNPQVVSDNR YRFATDDRYI LPRKTEHREM LRYLEDNIPS LAPPEVYGLH ANSGITRDLQ
     TTKTLLDSMI LLLGSEAAGT AGAGVSVEQI ILNTIKQIEG DMPADMDIEA AAEKYPVDYN
     ESMNTVVVQE MERFLKLQKE IRASCRDLAM GIKGIIVMTP DLENVMTAMK FNRIPLKWMS
     KSYPSLKPLG SYVQDLYKRL NWLFHWHMHG KPPTFWLSGF FFTQAFLTGA MQNFARKYKI
     PIDTLTFDYD VLKVETKASP PDDGVYCNGL FVEGARWEWE QNMLVEQHPK ILIYAMPVIF
     FRPVLIVELL EGSRYRCPLY KTGERKGTLS TTGHSTNYVV PLLLNTQAKP SHWVKRSVAL
     ICQTND
//
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