ID A0A3B0JT11_DROGU Unreviewed; 3966 AA.
AC A0A3B0JT11;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 28-JUN-2023, entry version 20.
DE SubName: Full=Blast:DDB1-and CUL4-associated factor 8 {ECO:0000313|EMBL:SPP85254.1};
GN ORFNames=DGUA_6G015161 {ECO:0000313|EMBL:SPP85254.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP85254.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; OUUW01000009; SPP85254.1; -; Genomic_DNA.
DR STRING; 7266.A0A3B0JT11; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF30; DYNEIN AXONEMAL HEAVY CHAIN 12; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 676..1102
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1240..1565
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1737..1869
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2089..2179
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2250..2511
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2533..2868
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2898..3119
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3364..3477
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3513..3652
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3660..3962
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2768..2816
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3966 AA; 454174 MW; AC19689AF5E9C4B5 CRC64;
MYSRKLSRMH RPPSDTSKYD NEPYMKNPLL KFRISDVHER RHYQFLKQKA ADVKVRIARQ
NWPPEPDIRP LPQSHYVDNL RREVRKIIVP PMLRKTEAKI LSFASERLRN RYPDLVDSYM
RDVHEEYNRL MKIYSMKNIL RHPEFSDEDP SKFELPQADF HFKRPGRTAN YSAYLENRRK
IGQKLLILQL PMRAVLSISV SDLPDVVCIF KYISATGAQQ QQMGLGGREA LSYKFYRKYI
QNQLDKVNTF LRWTWYPKLV IVLRKMLRKR VMTPALWKRA WSGLEGLMNR ELNNMKMRTF
IAMFRICSNP RTMPMFRMSL EWTEVSGELD TRPNLYSILR TFAEISTEIS MVGYRMESLQ
PQVETLTSMA AYAKVNDYLK IEMNDNSLKD VIDKVQKIII ATYAEVTAYI DNFRNKYDAL
FSWEERDALN NFLAEPHAFE EYFARIDVYY EFINLLRSEP AVEYFVMAVI HNEPAIQGLR
NLAENLIAEI TVIIIREHIK AEEEICEEFE KIKYRALEIP KSTEELLESA DYMIHVKTVK
LAELTDRIQY CLQVGTNIVE LTEMSKYHFD LTIKTINWIK DINEICEYNA SQQEQFKFLF
EEHLQEVVKK LNSDIEEMLP KLAIIDDMSR PEKFRDSYII LQNFIDQLKT FDDYVAWINK
EEKLFKVAQT EYPTLEVIKS FVYPFAEIMK CCIDWQRYLN VWQDGPFEYL EPKFVESTTD
NYLKEFQKNQ KYYRVKIKQD LIDNPVCKFK GQTEDPDPAK HPVPLRLCTS MIQSIKDFTT
GVFVVNIMCN PALRKRHWKE MSEIAGFDVT PDAGTTLRKI LNSGLDHILD QFEIISISAN
KELQLWNALQ AMIKEWENKV FPTGPYKETG VTILNSLDDI QALLDDHILK TLTMRGSAFM
KPCEEEVRAW YEKIMRVNET LDQWGKVQAN YLYLLPIFSS KDIVAQMPEE GRLFTIVEQT
YSRNMGLVLR QPLVMETAPA SGLLESLQKA NELLEDISTG VSNYLEKKRL FFPRFFFLAN
DEMLEILSET KDPLRVLPHL SKCFEGINSL EFDANKNVLA MISSDKEYIE FIEPVSTLAA
GGSVEKWLIG VEDEMLKAVR NQNELSYGHY PKVKRHEWVL EWPQMTVLAI SQVFWAAKMH
GCLRRSFGGN QTVMTNFFQE LSKELNDIVA LVRSPVISNL NRITIKSLIV IDVHAKDVTE
ELIRLKISSE YDFQWLAQMR YYWEEEQTLV RIINATVPFA NEYLGNSDRL VITPLTDRCY
RTLVGAYQLH LNGAPEGPAG TGKTETTKDL AKALAVQCKV FNCSDGLDYK AMGKFFKGLA
SCGAWACFDE FNRIELEVLS VVAQQILLII QAVRANVSKF MFEGTELMLN PAVYVCITMN
PGYAGRSELP DNLKVLFRSV AMMVPDYAMI GEISLYSYGF VDARKLAVKI VTTYRLCSEQ
LSSQNHYDYG MRAVKTVLSA CGNIKKQYPD ELEDILLLRS LIDVNLPKFL SFDVPLFEGI
ISDIFPGISL PHIDYSLFET EFKRVCKEEV LEPAPSFLTK VIQTYEMIIV RHGFMLVGEP
LAGKSKTLQV LAKVMSALKI KAPDKSSYFQ HVLMGIMNPK SITMNQLYGS FDPISYEWTD
GLVAKIFREF AMTPTPDRKW VIFDGPVDAV WIENMNTVLD DNKKLCLTSG EVITMSHEMS
MIFEVMDLAQ ASPATVSRCG MIYMEPSTLG WRAFANSWLK KADPRWADAE GVEYVTAMLQ
WLLPQCQTFV RRHCSQFVRS GEFNCMQTTF DLIDMLLDEA IEENPEDYQK YIVGYFQAAI
LFALVWGVGG ILDTASRDKF DAFLRKIYDG EEAHPPEALG KMEVTPPVEG LIVEYVYVFK
QRGTWRYWPE LAKRMDVEET KTGVIVPTVD TARYVHLLKM HVNHKKRMLL VGPTGTGKSV
YVQNYLMNKL NQEEYETGFI TFTVMITANQ CQELLISKLQ KLKRGIYGPP KGMQSVLFVD
DMNMPVKEVY GAQPPLELLR QYFDYGHVYD LKDASKLYIN DVLIVAACGL PGGSRQDVYA
RFLNHFNVFS INTFSDDSMF RIFLNVALNG LRRSGHGQDV FVVTNQIVSA TQSIYKSVQS
EIRATPAKSH YIFNLRDISR VVTGCTLVRK ESVNDKKILV RVWYHEAMRV FYDRLVDDTD
RKWMFDKLNE CLKANFKDKV ENIFDKYCVQ VGDEQVFSME TANNVFFGVY FDEDSVPDER
RYEEVPSVEV FLKVALDSLD DYNSTRRSKM DITLFTFALQ HLNRICRIIS IQGASALLIG
LGGSGRQSLT KLATNMVQTS FFQPEITKNY GANDWHDDIK VILKEAGGMN KHTTFLMTEN
QIKMELFLQD IDCLLNQGEV PNIFPIDEKQ EVLEMVRLAA QGGNRNIDVS PLQVFSFFVN
RCKQKLHMVL SFSPIGDALR TRVRLYPSLV NCCTIDWYDS WPEEALQMIA KMSLVDVNVP
SEEIKMAIVD TCQYFHTTAA RATRAFCQQS GRHIYQTNAS FIELIRSFQT LIDRKQSETM
FAKMRYIGGL DTLANAAAAI SIMQRDLNAL QPKLVALAEA SRKMMLEINK ETLAASAAAE
QVKRDEEVAS VQAVAAQVLK NECEKDLAKA IPVLEDALAA LNTLKPADIT LVKSMKNPPS
VIKLVMAAVC VIKAIPADRV PDPASGKMVM DYWGPSKRLL GEMNFLPALK EFDKDNIPVE
IMKRIRKEFI PNKDFDPKVV AKASSAAKGL CQWIIAMDMY DDVAKVVAPK KAKLAGAEKE
YADTMSFLAE KRALAAALEE KVALLNIELD KANEEMKKTE EHAENCRNKL LRAEALIGGL
GGEKSRWNKA ADDLQDLYDH LPGDVLLSCG IIAYLSAVNL QARTECVNDW FQKVTSLQIP
CSKKYSITEV LGLEVTIQNW QLDGLPNDEF SSENAIIVSS SSRYSLFIDP QGQANNWLKN
MERKNRLNCV KFNQGNYMRV IAEAMEYGTP VIIENVQEEL EVPLDPILMH QTFIQGGVKH
ISLGESVVPL SPNFRLYMTC NLRNPHFLPE TFNKVTVINF ALTQNALMDQ LLSIVVAKER
PDLQELRITL TTEAAANKGA LRDAENLILK TLSASEGDIL ENEAAIQILG ESKGLSKDIQ
EKQEAAKETS AKIEAFRLNY KPVAVHSSIL YYSITDLPNI DPMYQFSLNW YINLYMYSID
TANKSKDLPR RIKFLVDGFT KNLYNNVCRS IFEKDKLLFS FILTARVLLG TGQVEMRHLA
HLVTNAKEST HMPPNPDPSW ITETVWLNVL RLEELKELRG IVDAFRRNLS AWQTIYDHAS
PEVQPLPAPW HDKTTAFEKI IVLKALRPDS VFLAVRKFIA ITIGDQYVSP PEFDISKSYA
DSTALTPLVF ILSPGADPLG SLLAFAEKMG QEETFQSISL GQGQGPIATA LIKSAQEMGY
WVCLQNCHLA ASWMPALEYM WENMDTFNTV PNFRLWLTAY PTPQFPVTIL QNGVKMTNEP
PTGLRENLMR SYNSEPINEY EFYAGCAKQD RAFTRLLYGI CFFHAVVQER RKYGPLGWNI
AYGFNESDLQ ISVLQLSMLL NQYEHVPYDA ISYLTSECNY GGRVTDNWDR RAIVTILADF
CNPQVVSDNR YRFATDDRYI LPRKTEHREM LRYLEDNIPS LAPPEVYGLH ANSGITRDLQ
TTKTLLDSMI LLLGSEAAGT AGAGVSVEQI ILNTIKQIEG DMPADMDIEA AAEKYPVDYN
ESMNTVVVQE MERFLKLQKE IRASCRDLAM GIKGIIVMTP DLENVMTAMK FNRIPLKWMS
KSYPSLKPLG SYVQDLYKRL NWLFHWHMHG KPPTFWLSGF FFTQAFLTGA MQNFARKYKI
PIDTLTFDYD VLKVETKASP PDDGVYCNGL FVEGARWEWE QNMLVEQHPK ILIYAMPVIF
FRPVLIVELL EGSRYRCPLY KTGERKGTLS TTGHSTNYVV PLLLNTQAKP SHWVKRSVAL
ICQTND
//