ID   A0A3B0JT97_DROGU        Unreviewed;       986 AA.
AC   A0A3B0JT97;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   RecName: Full=Apple domain-containing protein {ECO:0000259|PROSITE:PS50948};
GN   ORFNames=DGUA_6G003815 {ECO:0000313|EMBL:SPP75921.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP75921.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; OUUW01000001; SPP75921.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3B0JT97; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   CDD; cd01099; PAN_AP_HGF; 3.
DR   Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 4.
DR   InterPro; IPR003609; Pan_app.
DR   PANTHER; PTHR47327:SF13; APPLE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47327; FI18240P1-RELATED; 1.
DR   SMART; SM00473; PAN_AP; 3.
DR   SUPFAM; SSF57414; Hairpin loop containing domain-like; 2.
DR   PROSITE; PS50948; PAN; 3.
PE   4: Predicted;
FT   DOMAIN          63..155
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   DOMAIN          474..558
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   DOMAIN          591..678
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   REGION          177..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          896..949
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..236
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..277
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..334
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        896..914
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        927..945
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   986 AA;  112022 MW;  C039925E241C4DB1 CRC64;
     MRSPPHSRNR VPPTPGLHLN LNISVILSLC LLHVHDSGAK FVIPTRHSDL SSTIIIVEDA
     KACFRRVLAG KRIAPQWVRR SISCERVEEC MRECGLERRF MCEGFNYRLD PSGHGQGDCE
     LVEMPLSQMD LYSSANRRDS NLLRHPDYDY YERDRNAPSS CRRNACQDCS KGPLSSKPIY
     LKPITGPGPS SSGSAFGDRD RDRDRNHFRP PSPTSTAVDH YRGSSQDHQP GSSYEHRPFS
     SEYHGSHSAS SSSSSSSSSS YELSSHGSGS GYFGHTPPSS FGSDHSYVDR HDPPRFFPVR
     PDRWETLPSS SGYDGSAYRP PRPETDRIDK YRPPYRPGPD FSPYRPHEPS RPVHNYLDRD
     GSGSGHGPGP GPGPGSYKKP NKFVPYLIGG EENWGSYGGS YGGSNSKHTS YWGLNESQRR
     KDHDFNYFQL GTSAPHRESN SVLGYPGSSY EDDYPKRRND YRQQWTRRPG PDECSAKTSE
     GFRLHKTAIR HAYNVPTLTE CERLCSDQRP SFSCHTFSYR YNQASRDNCM LCDRPVNMLD
     YYVDIEPDRD YDIYSMSDDM DVCRQPPRRH DSLAPNSKAN TAISDPRNAQ CFFRAIDATR
     FFKSIVRDSL TVRSVGECEM ECIRSTKFTC RAFAYRYGQQ RHAGIIDNCQ LSDWPVRDMD
     KERHLILDAA FDIFERASYG HGCEIQPIVD EKHKKLCYLG YGSPARLLPP AIKKVISVPT
     ETACKKECIR FRETSPFKCY AFSYGSHASF HNCELSDLDQ TELKLDVHYT HTKERDFWLF
     AWNPFDWTCR DKVNTIGGSR VNNDRRMDIF REPGDVAWRH YAVSGKPCRR SSPCEKNLIT
     GFYSCETDGS EVGSWDYCCK ADHPCGYSKG FDYPWCFVGD ESDQWRKCSD RYYPGKNGTQ
     PTHSHLGLAS SKEQQKQKHQ PHSHPHPQPA TAASSEYSQH PPRPGGLQSL SDFAAARLWP
     VTYLYSEGPP NATEFSNFVD CNKESC
//