ID A0A3B0JUM8_DROGU Unreviewed; 1579 AA.
AC A0A3B0JUM8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Blast:Probable G-protein coupled receptor 158 {ECO:0000313|EMBL:SPP74778.1};
GN ORFNames=DGUA_6G002467 {ECO:0000313|EMBL:SPP74778.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP74778.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; OUUW01000001; SPP74778.1; -; Genomic_DNA.
DR OMA; AQTHSHV; -.
DR OrthoDB; 3430189at2759; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15293; 7tmC_GPR158-like; 1.
DR CDD; cd12913; PDC1_MCP_like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR043458; GPR158/179.
DR PANTHER; PTHR32546; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR PANTHER; PTHR32546:SF29; G_PROTEIN_RECEP_F3_4 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:SPP74778.1}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..46
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 47..1579
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017381960"
FT TRANSMEM 886..907
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 919..939
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 951..970
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 991..1012
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1038..1058
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1070..1094
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1100..1121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 882..1129
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 99..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1257..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1374..1405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1441..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1498..1579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..311
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..400
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1385..1402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1503..1523
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1534..1555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1559..1579
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1579 AA; 173948 MW; BDC457FE91AAD964 CRC64;
MSSNSSSSSS SRRRAAERQR LRPEACRLLL WLGMLLPLIL LQLGQGQGQA VAAAASDLEA
ATPIGSPRTR NKAEAETLMA AGDSFNIRHG RSRTSHLLHS TNINSNDTSG GTSLARPSPV
TPTPHPEAGG TTSAPVTHKI RKLHKKKINE SIRKSVDKSL GVLHPAKNHR SLAEAEHLQG
RPPTNDDEDH EDEDENEDTA ALSEVMQLAD EIDLENSLES AYQNVVVGLT ATPTPTPSPM
PQPQPQPTFP TVAAAVVKST STRATGAADG ALQRRPFLRA NIDDANYAED EAAMEDSQEL
DVDVDEDEDE PLSTTSMPKI VKFAPHHGAR TRLLPVNGSS WQGGKRGDES DTGRRSRDST
ESDYRLDYSH SRSENDAFNN DDNIAEVDAD DDDDDDDDDD VNAAKKQSNA RLPFEDLQLL
NDSSSRSRSR SLGSTTDGWM DDGNRNGGPG AEARSQANME VNQIHFEGEG ESEAVLDTSE
VTMDDGYPPE VQIDDNTKQL VIEDVEGTDD DTDAENMESN QLTADVINAR DSKIDLVSKF
LQYIEQQHLM GSNCVAGTSL NLGEGVVDRY AQDRFRVEAE VAVNRANMLT RIFKTTGQRV
QEDVNLLHAS VLSMVEFDDD IFAAGNCFDW NEHPAQPGLF CPFAYRLPPP NLGAIFAKDL
AMEYHYLGNT SEWFFLARKN AEKVIARNEQ YLKSFHLYSN RTEERIEDDT LAVKYEDGRW
SKPYYDCGGG NIWMLTYTVP FFGYENGSYH FKGTSGIDID LRRVDIDQCP QRHTPGTKRP
LNIFAGTDKC KQRTTMCEAI MGLGFRRGSY KCLCRKGFYF PDVVSLHKFF NGSLLEEEYE
KLMLGKNSTY NSNSEYECLP CAEGCDSCED SSPCIAALNW PMRTSILALA CIVIGLLPPA
AWFTFRYQQV KVVRAASPAL LRVIALGAFC IYCTNIVMYP NPNLYTCTAR IWLREIGFSL
TYGALMLKTW RISVIFRVRS AKAVKITDAA LLKRLGIICG AIGTCLLVRT LVSPPDVVVG
RTADDLKAFL CKTDWWDYTF TSMEVLFLAW GVRLCIMVRK APSEFNESRF ISMAIYNEFL
LTCFLNVSML FLQSPANPDL LYIIFFCHTQ LTVTLLLALI FGSKVYIVLR SGKSHQENIG
MGTKASGAKF NFRPQVRTFA NPSSMTTTTV PVAAENKLSD QEALEEIRQL SMQLQRIQEM
APPKGVAVMT ISSLLDGLKT SGGMMAVAAG HAAARQSALP LLALNAEMQK YNQQNINANG
RGGTASASAS GRTSIPTMVL ETPPSSTPPS TAYEERAINT ELSGDDFREQ LLRRTADGHI
ICSRCLDASK EHYYCCPPRS ACDHMGSPQQ EGSISFANIK LDCMCSQSED LDQDQDHTLR
QQQRQRRPAV RSAATNTPPP SCKRAPRNLL EADVCITYQI CDNCRSKYKL SGRRRSGSCT
QAQAQAQTHS HVQPGGATVQ SQAQSRSSEL LLDRSVSVAL AAAKAAHSTD DIVLYTSSTK
EKEEEEDGEE EQQQQDAEEE LPESAPDPAP APSLGNVSNV SNASNNSTSG SGGTTRPKRP
DKLVLDLNDR SKYTKEVSV
//
