ID A0A3B0JXF0_DROGU Unreviewed; 1418 AA.
AC A0A3B0JXF0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 08-NOV-2023, entry version 20.
DE SubName: Full=Blast:Breakpoint cluster region protein {ECO:0000313|EMBL:SPP86734.1};
GN ORFNames=DGUA_6G008997 {ECO:0000313|EMBL:SPP86734.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP86734.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR EMBL; OUUW01000011; SPP86734.1; -; Genomic_DNA.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13368; PH_BCR_arthropod; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 4.10.280.30; Bcr-Abl oncoprotein oligomerisation domain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR036481; Bcr-Abl_oncoprot_oligo_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR PANTHER; PTHR23182:SF1; RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}.
FT DOMAIN 692..880
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 893..1046
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1075..1198
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1220..1418
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 112..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1418 AA; 154827 MW; 0BBEB81085F3722B CRC64;
MSVFDDFQRL WMQRFPQSSL SDAWEQDVRA SLERHRVKIT ELGKELEQET LYVEYLERLL
SDVEKYRASG GDPTALFEAA SGSGSVSGSS SNGATTTAAA VEKEFKSSLN LRESSSLSVA
GGKDKDRLSL NTDNKYTHTS NAAGSGSRAG GSASGGAVVG NGNGNGSGGS SGLNSAPIAG
DKRGLEPSFE REDRDKDSGN EKDANGALHQ CITELAASIN SGGGVKRPEA VEAERESSAR
QPVRKTTSQY VTVIQVKEAK DKDGDEASSG NDQQPTPPST FSRYAPGAGS GLGAEPSAPP
LSPSLSSYME AKKKMPPRPP PKNIRRVEPP TIPSQQHHQL SSSPKRETAA YAGSTMPLPS
SSVGSGSLSS DSPGNSLERN IKPSDILRQK SSENLDAKYA NNRKTTPELG KFVTNPELME
ELGRKMVGKM DSLEHAKRSD ASSSAASGGS SSLGRTSSTP GRPLNPGRTG AGTVGASPTG
SLNKTAKLAV ADSSSTSSLE KKSRTSLQAS DAEGGAGSGG GAATQRSAGS KESLASQGIS
EVIKSYESVS SLSSESAKAA AHQSPADHEP YYDSVPLDNG DGEYVFIKPG RTGSSSSRDD
LSTPGSSTLP MAQGLSSQTS VVDPESPGRT SNYVNIDYFL QQSNETRSSS LDSDGEYEGP
PILRTISHDE QTTSQTTPGA LRKVSGNARG AKIRSILSSI IHSETIYVEC LNKMMQYKKA
IHATLGTSQP VIKEEEENTM FFKIDELFEV HTAFLSDLKT IVSHEGGDVL IGEAFKRLAD
MFELYSAFLH NYGQAIETVK KCSASNPQFK KIVATIVVNL QTEQSLTLED LLHKPVARVQ
INAMVFNDLL RETPANHPDH QPLRQAQKII QMFLNQFNVC QRLPTESNRN LRRMVRNSFI
VELVDGHRKL RHLFLFNDVI ACAKYKALGR DRIDYELKWF IPLKDITVYE EADSAAELKE
SSPANISQVK RNLRSVRDQL ILEANGVRTG DKYRRKLADL ESQLVLATPN LVLRLGNKAN
NKAVTFFLSS DFERSQWIDS ITSLKQKCNL PGANTINSLE VTAFIVAMQK GMKTEMGSYL
MRNTNDESLL VGDLHMSIQG LAGLEKPSDL YTCVEVDSYG HYFRKATTKI ICRSQTPVWN
ESFMLELEGS QNVRILLYEA KDRPLLRAKH ILKLSHSWLT ETQQMRTIKL SETLELSCSF
RFVPGELCRA TTKPGALFGV KMSQVLKREK RDIPFIISAC IREVERRGML EVGCYRVSGS
ASDLSKLKKA FESDAYEAEQ LLREVDIHSV TGILKTFLRE LPEALFTDQL YPRFFDTFST
LSNNNEATRI NELLKVFDEL PQANKASICL ILDHLIRVHE KEADNKMSLH NLAMVFGPTL
LRPGQTQVKQ KDPLAASTVD VMAQAGILYC FLQARIKN
//
