ID   A0A3B0JZB7_DROGU        Unreviewed;       960 AA.
AC   A0A3B0JZB7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   28-JUN-2023, entry version 12.
DE   SubName: Full=Blast:Ral guanine nucleotide dissociation stimulator-like 1 {ECO:0000313|EMBL:SPP76458.1};
GN   ORFNames=DGUA_6G006996 {ECO:0000313|EMBL:SPP76458.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP76458.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; OUUW01000002; SPP76458.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3B0JZB7; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00153; RA_RalGDS_like; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF312; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168}.
FT   DOMAIN          241..384
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          462..724
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          864..954
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          89..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          743..765
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          804..847
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..136
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   960 AA;  107951 MW;  A43AFE49BFF93951 CRC64;
     MNFTSQSNCK CPHSQHPHQQ SKPTLIKSHT CAYQLQDLAG YNRALMPPLD NTDFSSAWRH
     VNNNSTSKTC AYHHQKPSHH QLYHHNTCPR QKKASGMTGP AAGMCQHQQH QQHQQQQQQQ
     QQHRRSRSAS AKTRRNSSYH PYDDLDASSA VANAERKVVA SLKYLCACTG ATLRNLSKKT
     KDLHAKNYTY TKPTWRLWGE EHEKNAIFTV YLKKVRYHRP TPTASNDSDD EISHLEWETV
     RVRFVKAATL ARLVEALATD DGELESTFIN VFLSTYRTFS TPKQVLSLLT QRYDALHDKH
     LEELEQAQQS GQVEDPAYDP HASIHEQHKK TLVSALHVWL DGFPEDWHED NLQQILAFAT
     KRLKRSDLHI KVLNRLERLI RQSVYGNGGG VGGGGGGGGM ENNGLPWLTQ AQQAQFMIPT
     HYGSSYDLSD QFNGLYLTPM GHGPIYRGPT HFLQAFRFPH VPVRHFAEQL TRMDTDLFKR
     LIPHQCLGHT WARRDSGGSE TVVATINQFN AVLFRVVSSI LIDRLKPQER ALNISRWIDI
     AQELRMLKNF SSLKAIISAL NSNSIYRLSK IWEFLPKERM EVFTELARIC SEDNNAWTLR
     EVLKREGTAK NPDPGSDQTD RHLQKLILNL GTQTSHGTIP YLGTFLTDLT MIHTANPDYL
     TEDKLINFDK KRKEFEVLAQ IKLLQGAANT YNLQGDALFD HWFASMPLFD EREAFELSCR
     LEAQPPAPRK SVVSTNTSLT NTTASSTASI IGHRKTDSIH SNSSSGAGSQ FYCELNSSTS
     SRHNSLDRDA HHASLMSASS SVSNLSLDSS NSGGRQSGKL THSQSMGNGL KSNGNGTTIN
     GVGSPHINAQ LVQPTGVPPQ SAPDFYIIRV TYETDNIELD GIVLYKSIML GNNERTPQVI
     RNAMLKLGLE DDPDRFTLAQ VLPDKELVMP KNANVYYAVN TNYNLNFILR PRKDEGVAGS
//