ID   A0A3B0K0A8_DROGU        Unreviewed;       327 AA.
AC   A0A3B0K0A8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=protein-serine/threonine phosphatase {ECO:0000256|ARBA:ARBA00013081};
DE            EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
GN   ORFNames=DGUA_6G007384 {ECO:0000313|EMBL:SPP76798.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP76798.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:83421; EC=3.1.3.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00001512};
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DR   EMBL; OUUW01000002; SPP76798.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3B0K0A8; -.
DR   STRING; 7266.A0A3B0K0A8; -.
DR   OMA; LFCCWRN; -.
DR   OrthoDB; 5473812at2759; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008420; F:RNA polymerase II CTD heptapeptide repeat phosphatase activity; IEA:InterPro.
DR   CDD; cd07521; HAD_FCP1-like; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR011948; Dullard_phosphatase.
DR   InterPro; IPR004274; FCP1_dom.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR040078; RNA_Pol_CTD_Phosphatase.
DR   NCBIfam; TIGR02251; HIF-SF_euk; 1.
DR   PANTHER; PTHR12210; DULLARD PROTEIN PHOSPHATASE; 1.
DR   PANTHER; PTHR12210:SF171; PHOSPHATASE HERZOG; 1.
DR   Pfam; PF03031; NIF; 1.
DR   SFLD; SFLDG01124; C0.1:_RNA_Pol_CTD_Phosphatase; 1.
DR   SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR   SMART; SM00577; CPDc; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   PROSITE; PS50969; FCP1; 1.
PE   4: Predicted;
KW   Ribonucleoprotein {ECO:0000313|EMBL:SPP76798.1};
KW   Ribosomal protein {ECO:0000313|EMBL:SPP76798.1}.
FT   DOMAIN          85..243
FT                   /note="FCP1 homology"
FT                   /evidence="ECO:0000259|PROSITE:PS50969"
FT   REGION          262..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          304..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            151
FT                   /note="Transition state stabilizer"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR640078-3"
FT   SITE            189
FT                   /note="Transition state stabilizer"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR640078-3"
SQ   SEQUENCE   327 AA;  37537 MW;  18255CB2834120A9 CRC64;
     MDATSIITQV SRDDEQLNVY PSYPNDKDDV ERLKPQKRGF IQSLLCCWRR NRTKTNQNGT
     QIDGSTTPPP LQDQQRYLLP QVRLTDVHRK CMVIDLDETL VHSSFKPIPN ADFIVPVEID
     GTVHQVYVLK RPHVDEFLQK MGELYECVLF TASLAKYADP VADLLDKWNV FRARLFRESC
     VYYRGNYIKD LNRLGRDLQK IVIVDNSPAS YIFHPDNAVP VKSWFDDVTD CELRELIPLF
     EKLSKVDSVY SVLCNSNQPL NNHQSNQLQQ HPQELQQAPN QLQQQQQQQT ISATTVITQA
     TTLSAPTMLQ QQSPSPPSPQ SELLQKT
//