ID   A0A3B0K0P8_DROGU        Unreviewed;       393 AA.
AC   A0A3B0K0P8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Lipase {ECO:0000256|PIRNR:PIRNR000862};
GN   ORFNames=DGUA_6G015577 {ECO:0000313|EMBL:SPP87814.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP87814.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|PIRNR:PIRNR000862}.
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DR   EMBL; OUUW01000013; SPP87814.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3B0K0P8; -.
DR   STRING; 7266.A0A3B0K0P8; -.
DR   OMA; STPSWHH; -.
DR   OrthoDB; 3518535at2759; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR006693; AB_hydrolase_lipase.
DR   InterPro; IPR025483; Lipase_euk.
DR   PANTHER; PTHR11005:SF100; LIPASE-RELATED; 1.
DR   PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR   Pfam; PF04083; Abhydro_lipase; 1.
DR   PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR000862};
KW   Lipid degradation {ECO:0000256|PIRNR:PIRNR000862};
KW   Lipid metabolism {ECO:0000256|PIRNR:PIRNR000862};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..393
FT                   /note="Lipase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017470483"
FT   DOMAIN          24..83
FT                   /note="Partial AB-hydrolase lipase"
FT                   /evidence="ECO:0000259|Pfam:PF04083"
FT   ACT_SITE        160
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT   ACT_SITE        329
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT   ACT_SITE        359
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
SQ   SEQUENCE   393 AA;  44685 MW;  33AFB47E2D523FFA CRC64;
     MAKVILGLLI LVPSILPVAP KDTADFIRER NYPVEKHTAV TQDGYVLSLF RIPYSPRRPS
     RPGPKPAVLF FHGLMCSSDF WVIISPEEGL PFLLADEGYD VWLTNSRGNT YSRKHLTLSP
     NDKKFWQFDW HEIGVYDATA SIDFILSTTG EKAVHYVGHS QGCTAFLAML SMRPEYGHKV
     KTSHLLAPVA FMSRVPSKLM RILKDFYLKM PDMETFYNVP PINRINKMMC SGYIIRNLVC
     RNIAFMFGGY ASPHLNMTLM PLIAGIAAAG VSTRQIKHYA QLIDSGRFAL YDFGAQLNLQ
     IYRSPSPPDY PLRDAYTQQP IEFYYSDNDA MSAVEDVEQV ISSLPNARGH RMAFKDWGHI
     DFIFAYNLKK HLNNDIINTF NTFESRYSGA YAN
//