ID A0A3B0K450_DROGU Unreviewed; 1403 AA.
AC A0A3B0K450;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Blast:Protein Gawky {ECO:0000313|EMBL:SPP88997.1};
GN ORFNames=DGUA_6G019188 {ECO:0000313|EMBL:SPP88997.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP88997.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GW182 family.
CC {ECO:0000256|ARBA:ARBA00007302}.
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DR EMBL; OUUW01000017; SPP88997.1; -; Genomic_DNA.
DR STRING; 7266.A0A3B0K450; -.
DR OrthoDB; 5407035at2759; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0035278; P:miRNA-mediated gene silencing by inhibition of translation; IEA:InterPro.
DR CDD; cd12435; RRM_GW182_like; 1.
DR CDD; cd14284; UBA_GAWKY; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR019486; Argonaute_hook_dom.
DR InterPro; IPR041971; Gawky_UBA.
DR InterPro; IPR026805; GW182_M_dom.
DR InterPro; IPR033503; GW182_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR13020:SF25; PROTEIN GAWKY; 1.
DR PANTHER; PTHR13020; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6; 1.
DR Pfam; PF10427; Ago_hook; 1.
DR Pfam; PF12938; M_domain; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00627; UBA; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 573..614
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 1..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1252..1389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 811..838
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 11..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1050
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1252..1382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1403 AA; 144180 MW; 7633B09CC1C9A07C CRC64;
MREALFSQDG WGCQHVNQDT NWEVPSSPEP TNKDASAPPM WKPSVNNGTD LWESNLRNGG
QPPAQQIPKP SWGHTPSSNL GGTWGEDDDG ADTGSVWTGG SVNNTGTGAA VSVNPSGVNV
GPTVVPTAGP QWGQGVVGVG VGLGSTGNNS GSGTSGTLPV VTPGCGSGSS NISGASGIGA
GGGNNAGNTG NGWGDPREIR PLAGVGGGPM DIRNVDHRET LRGGGSAGTS SGDPRDIRMI
DPRDPIRGDP RGISGRLNGT SEMWGHHPQM SHNQLQNMSK MVGQVSGSNV GATSGPGIGP
GSGGVSGAVS TNIANQWGPT QTVGVGGSVT KDKISGWEEP SPPPQRRNIP NYDDGTSLWG
QQTRVTGGGG GHWKDMTDSI GRNHLIRGQN QTVGIGIAGV GVGNSNVPVG GNPNNPMTSV
VGPQARLSSV SGVQHKPDGG TMWVHTNNVS GRNTAAGVNA WGDDSHNVGI GGPSGGSVSG
SNWVDDKSSA GLAQNSWSDT SSVGVGWGNK QSKLPSTSGS SGWSTSSSIG VGVVDGSDLG
SDWSAHGGIV KSQQQQKMAG LNVGMVNVLN TEMIKQSKQY RILVENGFKK EDVERALVNS
NMNIEEAADM LRANSSLAMD GWRRHEESLG SYSDHSSSTS SGGFAGRYPV GAAQPSMSFP
PNNLMNNMGA AAVTGSGSNN SNMAAMQVQK YLSQGPHGVA VGPQSVGNAS AVSVGFGQGS
SNAAVAAAAT VNIAANTNNQ PSGQQIRMLG QQIQLAIHSG FISSQILTQP LTQTTLNLLN
QLLSNIKHLQ AAQQSLARGG NANPMAVNVA IAKYKQQIQN LQNQINAQQA VYIKQQNLQP
NSQQQQQQQQ QQPQQHQSAH LNNSGNDYMR GHDAINNLQG NFSELNLNKP SGYQGASNQQ
SRLNQWKLPV LEKDDGTDFS RAPGATKQNV SSNSNNMGSL GLQNDGTWST GRNIADGWPD
PSSDNENKDW SVAQPTTAAT AYTDLVQEFE PGKPWKGSQI KTIEDDPSIT PGSVARSPLS
INPTPKDADI FANTGKNSPT DLPPLSLSSS TWSFNPNQNF PSWSDNSQQC ASTSELWTSP
MNKASSRGPP PGLTTHVNKS GNGVSGSTST SSTIAGGANG WMQTRSGVPT TNTTWTGGNT
SWSSSWLLLK NLTAQIDGPT LRTLCMQHGP LVSFHLYLNQ GIALCKYTTR EEASKAQMAL
NNCVLGNTTI FAESPSENEV QNILQHLPQV TSSTISAIGS SAGSSVAATA AGGSSSVSSL
SGNSSNGNGN GNGGGGPSGN SSVSGSNPST SVANSNLLST SGGSVSSSGG AGGSATGPVG
STTVNSTSLN GSAGPGNSAN PKSTTNNITM SGGQSGASGL TNSNSSTWRQ TTQNQPLSGQ
SRPTGREADY DYISQFVCSI VDD
//
