ID   A0A3B0K550_DROGU        Unreviewed;       782 AA.
AC   A0A3B0K550;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Blast:Glutamate receptor ionotropic, kainate 2 {ECO:0000313|EMBL:SPP87822.1};
GN   ORFNames=DGUA_6G015587 {ECO:0000313|EMBL:SPP87822.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP87822.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC       family. {ECO:0000256|ARBA:ARBA00008685}.
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DR   EMBL; OUUW01000013; SPP87822.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3B0K550; -.
DR   OMA; AQYENFG; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR   CDD; cd13714; PBP2_iGluR_Kainate; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR019594; Glu/Gly-bd.
DR   InterPro; IPR001508; Iono_Glu_rcpt_met.
DR   InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR   InterPro; IPR001320; Iontro_rcpt_C.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR001638; Solute-binding_3/MltF_N.
DR   PANTHER; PTHR18966:SF349; FI04462P-RELATED; 1.
DR   PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00060; Lig_chan; 1.
DR   Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR   Pfam; PF00497; SBP_bac_3; 1.
DR   PRINTS; PR00177; NMDARECEPTOR.
DR   SMART; SM00918; Lig_chan-Glu_bd; 1.
DR   SMART; SM00079; PBPe; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:SPP87822.1};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        439..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        515..537
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        704..726
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          308..678
FT                   /note="Ionotropic glutamate receptor C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00079"
FT   DOMAIN          319..383
FT                   /note="Ionotropic glutamate receptor L-glutamate and
FT                   glycine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00918"
SQ   SEQUENCE   782 AA;  89179 MW;  945DB18288E443B6 CRC64;
     MSICDAMDIP HIYSYMSEYA EGFNLHPHPA DLAKALYSLI TEFNWTRFIF LYESADYLNI
     LNELTTLFGM NGPVVTVLRY DMHLNGNYKQ VLRRVRKSVD NRIVVVGSSE TMPEFLNQAQ
     QVGIINEDYK YIIGNLDFHS FDLEEYKYSE ANITGLRLFS PEKMAVKELL LKMGYPSDQD
     EFRNGSCPIT VEMALTYDAV QLFAETLKNL PFKPVPQNCS QRTESVRDDG SSFKNYMRTL
     RLTDRLLTGP IFFEGNVRKG YHLDVIELQP SGIVKVGTWD AQREYRAQRL AATTAQFDNI
     DNSLANKTFI VLLSVPNKPY AQLVETFKQL EGNSQYEGYG VDLIKELADK LGFNFTFVNG
     GNDYGSYNKT SNESTGMLRE IMMGRADLAI TDLTITSERE EAIDFTIPFM NLGIAILYLK
     PQKATPELFT FMDPFSEEVW WFLGFSFLAV ALSFFILGRL SPSEWDNPYP CIEEPEELEN
     QFTIGNSIWF TTGALLQQGS EIGPKALSTR TVATFWLFFT LIVVSSYTAN LAAFLTIEKP
     QSLINSVDDL ADNKDGVVYG AKRTGSTRNF FLTSEDDRYK KMNKFMTEHP EHLTEDNQEG
     VRRVKTSTHY AFLMESTSIE YNTKRECNLK KIGDALDEKG YGIAMRKNWP HRDKFNNALL
     ELQEQGVLEK MKNKWWNEVG TGICATKEDA PDATPLDMNN LEGVFFVLLV GSCCALLYGI
     ISWVLFVMKK AHHYRVPLRE ALKEEFQFVV DFNNYVRVLK SSASIYSRSR QSSMSVASMA
     DS
//