ID   A0A3B0K644_DROGU        Unreviewed;      1331 AA.
AC   A0A3B0K644;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE            EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN   ORFNames=DGUA_6G018403 {ECO:0000313|EMBL:SPP83540.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP83540.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR   EMBL; OUUW01000007; SPP83540.1; -; Genomic_DNA.
DR   STRING; 7266.A0A3B0K644; -.
DR   OrthoDB; 3145419at2759; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd16541; RING-HC_RNF123; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR045129; RNF123/RSPRY1-like.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13363:SF5; E3 UBIQUITIN-PROTEIN LIGASE RNF123; 1.
DR   PANTHER; PTHR13363; RING FINGER AND SRY DOMAIN-CONTAINING; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   Pfam; PF13920; zf-C3HC4_3; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          74..253
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   DOMAIN          1264..1302
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
SQ   SEQUENCE   1331 AA;  151251 MW;  2A900ACF36DEFEDB CRC64;
     MSISKLFVKV FNENIFDQLD QENPYSDLDD DLEGANCSTL PESKPLKIDE LSVSKQMTIV
     KTWLDDKFQQ IQTDSNEEIR RLYAETESRI GPDLTIFDVD YTTTVRVSSD RLALRSQGSF
     NTVRTNCCVY GGRWMYEVQL HTKGVMQMGW ASSLCQFNEN SGVGDTKLSY GYDGSKQQIW
     HISTKKYGDK WQIGDIIGVT LDVDKELIEY YRNGRSMGVA FNKLEKGPGI AFYAAISLGY
     TQGIQANFGN RPFVYPVPGF QPLMARPILK LRRANLLMNY LTNLAGIFAK YNAQYKASAN
     QSEARVSTKK TVYCIFATML IERFTNEIFD SYIIEDVLLA RISSMTSLTA EKENPHSVLQ
     GLLSLFWNFM EGDEIKFVLR KMVNALLSTF THTVQGLDYE KHRQALAMLH CLCLNEQTRK
     FLLEGKLFKK HCIAFFLYIH PLEFYIMEEL LPDYMAWTEG IDGPKEKYLG IVEKVRKVTE
     PLYAAQKDFL STLMINRDGT PTSPSSRTLF LAKMRRYVID LSMEQRPFHA FFFMQSSIQH
     PLDAPVALAF VCILIDQSRN MFREELPGKN VEVNADYFFD GTFDYMHFDR VGGVLSHLRK
     VHRSDIDARL GSVRTQQIYD EDRSNSRTNE MDTTLYLLGE NVHNVAVIGH TQGTNNTTFT
     HFLNPRTNQG GEATPGNADA EASLCELLDL CIIFYYSAGH KYIVKIASVR DEIAALNDVL
     KETKYYREDV ERKLLALEQH ANVCMNDGHQ HVMGELRAKF SQRQNVFATR SISLSRKQIW
     LRGVALNNQR RSLLIWMLER MIRTLTNASN TGPLFAFVPE VYVNTLPILL DAVMDFSHHD
     MKAQFEATDS ECAVTSAAEF LGVHSADPRI VLASCKDSLL QALGTLTCHK AGVRALERSS
     RKSQVALVRA LLRPYENRAW GQSNWLLLRF WMGEGYAYKD SRQPCVWQGG SLPLHMGLCR
     SRSKNETHTG LLHNVAPANP SKHFQRLIGS KLIEDEPFAT SFLNSVLSQL NWAFSEFILL
     LQEIQNTAQR QENTLFEPKQ LKICSMCFEL TVSLMRCLEM IITVAPEIVT DPSRPNSDLL
     LNRICQLISQ VLSRVTVPPG CFQFVVDMCS ADLNAVTHFP IITAALGILL ALMRSEMDVD
     ITPQKVTRLS RAFLTDPSFQ FATLEFALGE IRTPLLEQKD IPRGNFDPSA RPHIDPLTND
     LRVPFPTNSK RIRADPPIIK FALTDFPTHV NSEEIDNIRR LIDGLRMKQT LLSDITLPSE
     DSLCPICCAK PITAVFTPCK HQSCSDCIMQ HMMNSKVCFY CKTTIHTIET LDGTLIYSNE
     DVMQTPMNER A
//