ID A0A3B0K700_DROGU Unreviewed; 536 AA.
AC A0A3B0K700;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Blast:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 {ECO:0000313|EMBL:SPP89987.1};
GN ORFNames=DGUA_6G020737 {ECO:0000313|EMBL:SPP89987.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP89987.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the phosphoglycerate
CC mutase family. {ECO:0000256|ARBA:ARBA00008408}.
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DR EMBL; OUUW01000044; SPP89987.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B0K700; -.
DR STRING; 7266.A0A3B0K700; -.
DR OMA; RWIQERC; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR GO; GO:0006000; P:fructose metabolic process; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR003094; 6Pfruct_kin.
DR InterPro; IPR013079; 6Phosfructo_kin.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001345; PG/BPGM_mutase_AS.
DR PANTHER; PTHR10606:SF44; 6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM; 1.
DR PANTHER; PTHR10606; 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE; 1.
DR Pfam; PF01591; 6PF2K; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR PRINTS; PR00991; 6PFRUCTKNASE.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00175; PG_MUTASE; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:SPP89987.1};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000313|EMBL:SPP89987.1}.
FT DOMAIN 73..285
FT /note="6-phosphofructo-2-kinase"
FT /evidence="ECO:0000259|Pfam:PF01591"
FT ACT_SITE 293
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT ACT_SITE 378
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT BINDING 292..299
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
FT BINDING 342
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 536 AA; 60914 MW; 2FD1BD137C91E368 CRC64;
MDMPYNTSPS LRVRTTSLNQ LKKTADLAIE NELHVCPSVM SEELRKLLPP TSETVMTKPF
PIRGERTIAD CTTPHVIAMV GLPARGKTFI SKKLARYLNW IGIATRVFNL GEYRRHATTA
YKSHEFFRAD NEEAMAIRNR CANQALHDSC EWLLSGQGSI AVFDATNSTR DRRQLIYNIV
VKQHGFRLFF VESICDDPQI IEQNILEVKV SSPDYLNMNT ELVVRDFLQR IEHYEERYQP
IDEVTESHLS FMKVYNAGKK VVVYNNEGHV ESRIVYYLMN IHITPRTIYL TRHGESEHNL
SGLIGGDSNL SARGHQYGRA LSSFISQQHI DGLRVWTSWM KRAIQTVANV KAPQERWKAL
NEIDAGHCEE MTYEQIKERF PEEFKARDVN KFAYRYPRGE SYEDLVARLE PVIMELERQG
NVLVVSHQAV LRCLFAYFLD KSADELPYLY VPLHTVIKLT PVAYGCKVEH IKLPIDAVDT
HRPKPKIPGD VSEPGLDGLS GELVAPDGVG KVLIVGDDVA TATNVNGARV DSQPNQ
//
