ID A0A3B0K7U7_DROGU Unreviewed; 2503 AA.
AC A0A3B0K7U7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Blast:Protein lap4 {ECO:0000313|EMBL:SPP81071.1};
GN ORFNames=DGUA_6G006053 {ECO:0000313|EMBL:SPP81071.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP81071.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR EMBL; OUUW01000005; SPP81071.1; -; Genomic_DNA.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF44; PROTEIN SCRIBBLE HOMOLOG; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF00595; PDZ; 4.
DR SMART; SM00364; LRR_BAC; 9.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00228; PDZ; 4.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50106; PDZ; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 732..819
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 935..1025
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1167..1257
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1264..1356
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 427..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1125..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1377..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1485..1507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1589..1936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1981..2007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2070..2173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2216..2256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2281..2314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2418..2503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1377..1405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1485..1506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1589..1622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1630..1645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1657..1672
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1707..1730
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1750..1790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1799..1813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1845..1870
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1873..1925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1988..2003
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2125..2142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2216..2254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2430..2448
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2468..2503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2503 AA; 271062 MW; E63E5B00B2606597 CRC64;
MFKCIPIFKG CNRQVEFVDK RHCSLPQVPE EILRYSRTLE ELFLDANHIR DLPKNFFRLH
RLRKLGLSDN EIGRLPPDIQ NFENLVELDV SRNDIPDIPD DIKHLQSLQV ADFSSNPIPK
LPSGFTQLKN LTILGLNDMS LTTLPADFGS LTQLESLELR ENLLKHLPET ISQLTKLKRL
DLGDNEIEDL PPYLGYLPGL HELWLDHNQL QRLPPELGLL TKLTYLDVSE NRLEELPNEI
SGLVSLTDLD LAQNLLETLP DGIAKLSRLT ILKLDQNRLQ RLNDTLGNCD NMQELILTEN
FLSELPASIG RMTKLSNLNV DRNALEYLPL EIGQCANLGV LSLRDNKLKK LPPELGNCTV
LHVLDVSGNQ LLYLPYSLVN LQLKAVWLSE NQSQPLLTFQ PDTDAETGEQ VLSCYLLPQQ
EYQPITPARD LESDSEPFEE REPSRTVVKF SEEATQEKDT PFVRQNTPHP KDLKAKAQKL
KVERSRHEEN ANLVTLPEEN GTKVAETPTE TRTLANNHQQ APPQQVQQPI VGVNSKQTSS
NNSSIPTGGA PAAPAAGNNS SHNNTKAAPA AAVVEIVAAA ATVAASEDVL DDDEQEDEFE
SDRRVGFQVE GEDDDFYKRP PKLHRRDTPH HLKNKRVQHL TDKQANEILA NALATQERNE
TPTPPHSSLG KVTSPIEEEE TADVDSEGQE QSQHPFDVSL SPIPIPTGNT KAQAGDQDNL
DGVTELRLEQ YEIHIERTAA GLGLSIAGGK GSTPFKGDDD GIFISRVTEQ GPADMAGLKV
GDKVLKVNGI VVVEADHYQA VQVLKACGAV LVLVVQREVT RLIGHPVFSE DGSVSQISVE
TRPLVATEVP QLQQQPERYI PAPIEIVPQQ HQYQQQQQMV APAHGYSANV FATPPAVQSI
VQPTPAAAAA AAAVAPNGLL PNGRDAAQLS YIQLHTTLIR DQIGQGLGFS IAGGKGSPPF
KDDCDGIFIS RITDGGLAHR DGKIMVGDRV MAINGNDMTE AHHDAAVACL TEPQRFVRLV
LQREYRGPLE PPTSPRSPAV LNSLSPSGYL ANRPANFQRS VGDVSYVEQP YKYNTLATTT
PTLASATVAP VAANINNNNT LPSSKTNGFG AATAASAAGP AIVFDKTTGQ PVPAPRRTNS
VPLGDGDSAP PNGAASTASG DSGEAQEVVL PKNQGSLGFS IIGGTDHSCV PFGNREPGIF
ISHIVPGGIA SKCGKLRMGD RILKVNDADV SKATHQDAVL ELLKPGDDIK LTIQHDPLPP
GFQEVLLSKA ENERLGMHIK GGLNGQRGNP GDPSDEGVFV SKINSVGAAR RDGRLKVGMR
LLEVNGHSLL GASHQDAVNV LRNAGNEIQL VVCKGYDKSN LIHSIGQAGG MSTGFNSSAS
YSGGSRQGSR ASETGSELSQ SQSVSSLDHE EDERLRQDFD VFATQKVESV LEPTSQTGLA
AAAALVHGAP SPTPTTPTPP VAVADLPAPS DSTAAQTVAL IHAEQAHHQN QQQQQPQTQL
APLGQEKSTQ EKVLEIVRAA DAFTAVPPKS PSEHHEQDKI QKTTTVVISK HTLDTNPTTP
TTPSALLPPI GSAPESVTAV APPTPASVPA VAVQTQAPTE KSEEELVPQQ RGTQTPEHLT
PGARFSYQQM LEHQEEHRNS AKATPAKPKK AEPVYIIDDD DDDDEEDVDD SHQHLDDIDA
IDEEDEEEVE SSPPLDLQSP PSYAESDSDC FDRRRGRYTS DSESDCRPYK PSRSGRSTPE
YGGGHRKSVS FDLSGDERSR SDYERSRSRT PDGYTRAYDS EQDNRGNARN RMPRKGILRA
TSPSSSTSST LERRPEKLAP IVPTVARIRE VESPQLQRVS RATSPERPAE LERENPFRHP
PIEDDEYTQI AKAINRSPRS PRTTRDQFFF GSARSSEDLL EQSFSSGRST PNTVISKSTE
NLTGTRPKVP PKPQLKKADL VRNVALETFQ ASDVGQGDFT VFEHDASTNT IHPVGAKVPV
RVSTKTPPRP RESPPPPPVN YSTLPKSPLA STVPTVLEES LYMEALPGPP PSHRRPHEFV
HENSPDNILV TPQEHREYLL RENELRNQLR APYDPAPPIP IAGRASGSGS GSGGHAVTNP
FLDSCDTDID SLPLPPPPTP PTEQAPSQLH HYLQNQHQNQ YHSHPTRHLH EPAPGPPLTA
VATNASTSPS SSNAAGRLLM DVVARSPQQL LVAGSPTQIF PTAQILPVQY ASLPQPQQPN
TLTLTPSQSQ TQSQTQPHSQ SQSHLQSPPQ TQPIFNFVLL PGDQGQVSSL YLQSVQSPSL
PAQKSVSESS GKPPQQQFLA PPSNDSSSPS PSYTAMKFPT FSEILVSPDS NSNYQNMTTS
RAGISNSSLA TSSSFSIDSS STSSLQIKST AAAGTGTGTG TGTGTGGLAS YYETAEEIYS
TIEEAIYSNT SFFDSRRSSD TSLSCRASKS PTPPPLPPKR PLKPNIVRTA PAPPVAQKPH
GLRGLASFKL RSSQSQPQLE AQSWARSPVS HTPTTPTGKE TTV
//
