ID A0A3B0K9J6_DROGU Unreviewed; 1359 AA.
AC A0A3B0K9J6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN ORFNames=DGUA_6G020922 {ECO:0000313|EMBL:SPP90033.1};
OS Drosophila guanche (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP90033.1, ECO:0000313|Proteomes:UP000268350};
RN [1] {ECO:0000313|Proteomes:UP000268350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR EMBL; OUUW01000052; SPP90033.1; -; Genomic_DNA.
DR STRING; 7266.A0A3B0K9J6; -.
DR Proteomes; UP000268350; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF51; ANOCTAMIN-8; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 312..337
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 423..447
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 506..529
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 649..670
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 700..718
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 725..746
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 301..769
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 776..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 956..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1089..1228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1321..1359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..1003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1359 AA; 150489 MW; EC05FA3F9FDA839D CRC64;
MSQSFDSSHG SGSVGPRLGY PERQSSEDVP ESTATATTET GTATTTAGDG QQGAGVGAGG
EDNITDDNFE SNLRRRKGKI ISCAKETIEN ASRHIRRKVP YAGHLMTPRR LWLNKIPTQC
DVVIEFPEDS PDEALRWLLA RIRSQPPAGL GLLVQVKAHE STRRNAFYVS APVNVLFKAA
EEARLPKRLR PDLGSALREF TTRESHCFQQ LRGDVASTAL FTSQERQWLV LQVLQGLRAG
CSDIDALHGR AAVAEGQSIV AAWQESGLIT QVFPLHEPRS LTQLQTHWVK QIFAPQPLDD
IAAYFGVKVA LYFAWLGHYT CALGVPAIFG TILYCILWGK GQTAQDMGHV LFSLFNVAWA
SLYLEAWKRY SVELAFRWGT LSTPPELLEP PRPLYKGPLE ENNVTGRLEP KESPAWQRRA
FRYLVSFPII GCCLCMVFAV MFLMLRFQDW WDSKLPEDSV LCCLSVIPKV LLAGAITLMD
EAYFKLAVWL NDKENYRLQS KYENHLIAKV ALFQFVNSFL SLFYIAFYLR DEEKLKEQLA
GLLISRQIIG NLRESALPYF VEQYKLAKLS FNMWGALSPT QNLTRSLAEE LATAEAELKA
EASGTPTKTH QQSQEASKRN IGQAEIESSL YKYNGTFSDH LEMLVQMGYV VLFSAAFPLA
GMCALINNLM EIRSDAFKLA HVHQRPFGQR VANIGTWQNA LSILSLAAVI VNCALIGLSG
QVSRLWPGLT TAQTIILIVT LEHIMLGLRQ ALTWLLPELP SWLAAEIARA EHCRREMQCK
GTSPRPTPPT PQSTTSTQPE QEGSRGMLQP ESGANTTHDQ CMESQVAEDM LLYGHEFATS
GYGRNIEADV NIYENRDSSP DSPPSQTSTI LIRPLHESTP PHGGASLSSL HYDGNGGACV
RKSLHFIPEI PPFLGYSVRN LSVMTKQQQQ IGASASTLAL NSAAFAARMQ PIHLPEIPPF
RKKSSDSADH TGSSNSSSPQ RATMRQLSAQ YQPQQQLQQE HQQRISEIPP FKTRKISAES
ATHLTLSDKL HIKLHAPEWM SRLKVNDNAI LHRSIDCIAK ELANSDNTSD ILKPAPSWSN
VALKTGTPGS LLATPPASQQ QHHIVASSSS SSGGGGSVFS TSGLGPNGAS GRISNSQSRP
SVGALSNSSS SSSHKQQKKL EKEEKEREKK EEKERGRERK EEKEKERKEE KEKEKQREKE
REKEKERDKE KEKEESAAAS TSAGALDDEA KAAELAAKKS RLKQKLVKSA RSVAIFSLKL
KERRQREAEK AATIAVEHAK ALAKLPIHQA VGGELSLIPI EQLIQIEDLQ PAIKPLTANV
STTTAPTSTS SLAGTSMQHQ HHHQYQQQQY HPPHPHTDD
//
