ID   A0A3B0KD75_DROGU        Unreviewed;      2061 AA.
AC   A0A3B0KD75;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=Nipped-B protein {ECO:0000256|RuleBase:RU364107};
GN   ORFNames=DGUA_6G013274 {ECO:0000313|EMBL:SPP81598.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP81598.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU364107}.
CC   -!- SIMILARITY: Belongs to the SCC2/Nipped-B family.
CC       {ECO:0000256|ARBA:ARBA00009252, ECO:0000256|RuleBase:RU364107}.
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DR   EMBL; OUUW01000006; SPP81598.1; -; Genomic_DNA.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR   GO; GO:0009790; P:embryo development; IEA:UniProt.
DR   GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR026003; Cohesin_HEAT.
DR   InterPro; IPR024986; Nipped-B_C.
DR   InterPro; IPR033031; Scc2/Nipped-B.
DR   PANTHER; PTHR21704:SF18; NIPPED-B-LIKE PROTEIN; 1.
DR   PANTHER; PTHR21704; NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED; 1.
DR   Pfam; PF12765; Cohesin_HEAT; 1.
DR   Pfam; PF12830; Nipped-B_C; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU364107};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364107};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364107}.
FT   DOMAIN          1649..1833
FT                   /note="Sister chromatid cohesion C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12830"
FT   REGION          135..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1036..1061
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1991..2039
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..340
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1036..1060
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2005..2039
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2061 AA;  234362 MW;  4850E904553BF77D CRC64;
     MGDRDIPSVP VTTLAGLTST SDLLSELPVS DSLLSAASLN KSLLFHALVA SESDNLLSVR
     DGALVRQLVN AIEQTNSDNI ELKPEYTFEQ HGTNISTYPE LLQGIYNFRP TVFNTPLKIM
     RYDHNNAKEL TPSEHIVGQS HSSQQATASS TDISQKMQQT QTYIEKSSSL AATDVLPDEY
     SMIGSRTNMN EINKRMEKPP NLEENVTQTF PKNEEMDITH TIAENKNPNS SLYSAQQQYF
     SQLKVREYSL NCDNLKQVDN NPSFQRMPDE LLFLESPIYH LQPAMTESQA PTTSTSMIQG
     NFQNVLNIQQ QRITESAAHH KDQAKSLLPN TNNQLPTLTT NVPDLHLIPA TSTSIITSTA
     TSTSTSSSGK SEVRVCINRL NVEDTRLMQQ SIKKFVQKSP ELARSMGLLQ QSSEQQPNTS
     LNVMPMTELG VGEATTETLS TELDMFSTIK ADEKRYASKR KMAVSIGDIP PEQIFSKPKV
     RRVERIIAIA NSKDLKDEVT RSQTYQHFMR NMEQIIEMLD DTESPNFDSE HFDENIECIS
     PKLLNTMSND VAKLKAKQAL DSIPKNKLTL LINYAMRNVY LARNYFAGPE DEDEIVDDEV
     IDKILNAMDA CLLICNIYST VSDLKFLQED NISHIIKFAQ FQLRETIFPS HDPVYTVKSM
     KKSTNRKKIK SHQGHHRNLQ LFYSKTVELL KVFVALFDKC IFVDTIVLPL STLAIEPFFV
     DNIETLQFVC LELVTTIFRK ERYDKIRNSI LGDILSSIDR LPSSKKNLRP YKLTNNGGNI
     QMVTALVLQL IQCATILPDS LCDNVKTTAA FQLVVDNDDD PAKKIVKPNK DIVVLKKYDV
     AVSIGGNFLT TFLNKCKSRS NETDFRPLFE NFIHDLLATV NKPEWPASEL LLSLLGTMLV
     RYVSDKGIEQ SIRLVSLDYL GIVAARLRKD TVESRCKVNI IDSMIKSIKV EQEKEGDLSN
     SNAKIELHPE EQRTEFLQKI LLDFLAVNAQ EENLIWDYAR HFYLAQWYRD VIYQRRRIKD
     GEKGFALRKS KSRDKRKTGE YLDTSDSESG EDHYNEDTKK NGNPPIDLID YELNLEIFNV
     LEERKQYLIS KIKPYSVSGE QHHTSQQQIK TYIDYNNAQL IAQYLATKRP FSQSFDGCLK
     KIILVVNEPS IAVRTRAMKC LANIVEVDPL VLKRKDMQMG VNQKFLDTAI SVREAAVDLV
     GKFVLSNQEL IDQYYDMLST RILDTGVSVR KRVIKILRDI CIEYPDFAKI PEICVKMIRR
     VNDEEGIQKL VTEVFMKMWF TPCIKNDKHG IQRKINQIID VVNTAHDTGT IWLEGLLMSI
     FKPKDMLKND GSIQEPVKKN TEPPQEIVLA CQQLADGLID RLIELEDTDN ARMLGCITTL
     HLLAKVRPQL LVRHAMTIEP YLNIKCHSAT AAKFICAVAD ILEKVVPLVN NASESFLASL
     EEHLMLLVVS RNQAEVTSCV SCLGALVNKI TKNYKLIRDC FQKFYRVLDV SRNQVLQKNC
     SADNIYTPSF RRSLFTIGIL MRYFDFKSPI ALGETNGGLP VSICDDVFEC LMFFCRCSNQ
     EIRKQALISL GSFCVLNDDY LTRSELKQFY CDLLNSTASD GGIKIICMRN IWIYLTESEM
     FMHNKEKEWE KQSKHEDLKE MNDVSSGMSS RIIQLYLEEI LNCFLNRDDT VRLWAVKVVH
     IVLRQGLVHP VRMVPYLICL STDPKIESAH RADALLKDID KTYSGFVNMK VQFGLQLCFK
     LQQILQINNR GKLEIIRGYA KRGPEKVTTA LNDFLYTLLR STKPQRRALV QTVTKQFDDQ
     KTSLQQMLYI ADNLAYFPYV VQDEPLYLIH QIDLLISMAG THLLATFKEH LNPNEKEGDV
     LEDEDDVEDP QVLFNRLPED MTEIKKCITS AQACMLLLIL KDHLKDMYGL TDGKISRYSP
     SEQKMYEKAI TRRSVVDFNP KTTIDLIKKQ KSHDLSDSEP DCSSRPLTDD EKLDLVVKYL
     DFKQLMLKLD PEDGDSEGDE IREKSNLNNS SISDGVVYLN STKGSQPSNN DSSFCSTPNV
     SHVQSSITAA TSTDVHQGPK S
//