ID   A0A3B0KP94_DROGU        Unreviewed;       628 AA.
AC   A0A3B0KP94;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Blast:Hairy/enhancer-of-split related with YRPW motif protein {ECO:0000313|EMBL:SPP87686.1};
GN   ORFNames=DGUA_6G015430 {ECO:0000313|EMBL:SPP87686.1};
OS   Drosophila guanche (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7266 {ECO:0000313|EMBL:SPP87686.1, ECO:0000313|Proteomes:UP000268350};
RN   [1] {ECO:0000313|Proteomes:UP000268350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Alioto T., Alioto T.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; OUUW01000013; SPP87686.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3B0KP94; -.
DR   Proteomes; UP000268350; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR003650; Orange_dom.
DR   PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR   PANTHER; PTHR10985:SF141; TRANSCRIPTION FACTOR CWO; 1.
DR   Pfam; PF07527; Hairy_orange; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00511; ORANGE; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF158457; Orange domain-like; 1.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS51054; ORANGE; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125}.
FT   DOMAIN          1..40
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          51..82
FT                   /note="Orange"
FT                   /evidence="ECO:0000259|PROSITE:PS51054"
FT   REGION          172..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   628 AA;  67162 MW;  1B11E87E51C9201C CRC64;
     MNSCLADLSR LIPPQYQRKG RGRIEKTEII EMAIRHLKHL QSECLQKESD YRSGYMDCMK
     EAAKFLYDVH MQDFCHRLLG RLQEHIDDMF KTECYKSTRT CHMPDNVSAS SGSPHQAYHP
     PLCHLRDMLG ASDVEHSQDH NDVKDLSFRN HLNQLQRNQQ AAAAAAAAVA ANGSGSSSSS
     TTLEVASKLP MTNGSGSGSG SGNANGDNVP TNSTGSLPGA GSSSNAASST SCPSTVTCPT
     TTSASVAQKV APPMAAHQQQ QLPHQAAVIT STAPHHHTDS SHHDFDSSRE PILHTDTSNM
     HSPPPRDLLL QQHPHLGHNH TQDSLMSVRM RNYSESSHEV EHNNNYKYKN HIKERFVHEL
     HDEETSSEHC PVAAHLQSDH SHMQAHSDHS KDGTEPEIAP IMAKKRKMAE AAAAAAANGD
     VHPLDVHCDA SNPNPSRQLL MLREDSKPSP SFNFSDIKDI KSELHNSNSN SSPLLAKLSA
     AAAAGAQLST PSSTTTSLAP RHSFTVPIFA LHGQGNYYVP LNVDYNALVP FLNGMDLLEK
     SYSSMPVVHP ININVNFMPS SPSTSLLAAA AAAAAVAAGK QQQAVAAASA GGPLSSVVGA
     NSAAAQVAAV AAAAVAKAKL EQAMNSSW
//