ID A0A3B0M4Y2_9RHOB Unreviewed; 688 AA.
AC A0A3B0M4Y2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=recQ {ECO:0000313|EMBL:SUZ31175.1};
GN ORFNames=ROE7235_00911 {ECO:0000313|EMBL:SUZ31175.1};
OS Roseibaca ekhonensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Roseibaca.
OX NCBI_TaxID=254356 {ECO:0000313|EMBL:SUZ31175.1, ECO:0000313|Proteomes:UP000272908};
RN [1] {ECO:0000313|Proteomes:UP000272908}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 7235 {ECO:0000313|Proteomes:UP000272908};
RA Rodrigo-Torres L., Arahal R. D., Lucena T.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; UIHC01000006; SUZ31175.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B0M4Y2; -.
DR OrthoDB; 9760034at2; -.
DR Proteomes; UP000272908; Unassembled WGS sequence.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR01389; recQ; 1.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 2.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 2.
DR PROSITE; PS50206; RHODANESE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:SUZ31175.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:SUZ31175.1};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000272908}.
FT DOMAIN 32..199
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 221..371
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 238..273
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 527..607
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT DOMAIN 614..688
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 688 AA; 75285 MW; 22DA5DC3DC7001AC CRC64;
MQPCLSEGAD PQAILQQVFG FDGFRPGQAE IVESVAAGQD TLALMPTGGG KSLCFQLPAL
CRDGLTVVIS PLIALMRDQV RGLQELGVAA GSLTSGNTEA ERDAVFEAID RRDLKLLYIA
PERLASSGTL DLLRRARCTL IAVDEAHCVS QWGHDFRPDY LRIGDLRRAL DVPMAAFTAT
ADAETRAEIL KRLFEGRAPN IFLRGFDRPN ITLNFTVKDS PRKQILTYAG ARRGQSGIVY
CGTRARTEAL AQGLREAGHN ARAYHGGMEA DTRRAVEELF QREDDLIVVA TVAFGMGIDK
PDIRWVAHAD LPKSIEAYYQ EIGRAGRDGA PADTFTLYGP DDIRLRRSQI DESPAPPERR
EADHVRLNAL LGLAEAVGCR RQVLLSYFGE ASEPCGNCDL CARPVKLFDA TTPVRKALSA
MLRTDERFGV GHLVDILTGN ATDKVRARGH EHLPTFAVGR DLSRAKWQAV FRQMMGRDLV
RPDAERHGAL RMTEAARPIL RGEAEITLRE DTITTARDGP AVKALVSDED APLLSALKAK
RRALAETARV PAYVIFTDRT LIEMAETRPN SMDAMARISG VGATKLERYG AEFLAVITGA
MPDAQHPQRR KLAGREAGAL FDELAEVARG LERGADGTGK LLTLTPATLR AIAERRPAND
ADLARIRGMD DARMERFGAE ILSRLHSL
//
