ID A0A3B1DQX2_CAEEL Unreviewed; 830 AA.
AC A0A3B1DQX2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=MAGUK p55 subfamily member 5 {ECO:0000256|ARBA:ARBA00032294};
GN Name=magu-2 {ECO:0000313|EMBL:VAY52515.1,
GN ECO:0000313|WormBase:C01B7.4a};
GN ORFNames=C01B7.4 {ECO:0000313|WormBase:C01B7.4a}, CELE_C01B7.4
GN {ECO:0000313|EMBL:VAY52515.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:VAY52515.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:VAY52515.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:VAY52515.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR EMBL; BX284605; VAY52515.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B1DQX2; -.
DR SMR; A0A3B1DQX2; -.
DR STRING; 6239.C01B7.4a.2; -.
DR PaxDb; 6239-C01B7-4; -.
DR EnsemblMetazoa; C01B7.4a.1; C01B7.4a.1; WBGene00006467.
DR AGR; WB:WBGene00006467; -.
DR WormBase; C01B7.4a; CE52786; WBGene00006467; magu-2.
DR InParanoid; A0A3B1DQX2; -.
DR OrthoDB; 2878795at2759; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00006467; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; A0A3B1DQX2; baseline and differential.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR GO; GO:0016332; P:establishment or maintenance of polarity of embryonic epithelium; IBA:GO_Central.
DR GO; GO:0048699; P:generation of neurons; IBA:GO_Central.
DR GO; GO:0002011; P:morphogenesis of an epithelial sheet; IBA:GO_Central.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00136; PDZ; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd12036; SH3_MPP5; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR035601; MPP5_SH3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR PANTHER; PTHR23122:SF14; PROTEIN PALS1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A3B1DQX2,
KW ECO:0007829|PeptideAtlas:A0A3B1DQX2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 59..95
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 397..477
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 499..571
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 632..814
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 338..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 92875 MW; 06685ED08D10EC02 CRC64;
MSKSVSIPQA LSDLKRTSLR RLSSARGVGN KKTVVSTSTP LSGFVILVER EEKVVRLYGT
AAERAGLSIG DEIVGVNDMK IEGKSYEEVT TYIQECIRRK IIQLKVRRRA LEIPAENEAS
VFNCTNSNRM ITDAYLVSVD KDHIKEVTKR LKKEYPEIHT YDMEYIAATS GPPSVAPRGS
VHTNGFGIER GSLRRPPEQF EMQEKKRKEQ ENTFLRSSLR KSKKLQALAR NVDPLTNEPM
KVTSFANPLA EVEETPSRKT ENGATRITVG EEVLESSEVL IDEENKDSRQ LDEVIISVER
IASKLSSMQG RESDVAMLRD FFAAPPIQAA IEQTVKQNGK CGTTSSGIGT DSGGDSSSCT
SSPIPPVIMN GNGKSERCPS TSSSSSVSPR NAPNVKVVEV VKDEDSYLGA TVRNENNKII
VGRVVKGGIV EKMNLFQEGD ELLELNGSSL KGKQVNEICD ILRNLSGPIT FVVAPKEEQD
TEQPTDTATN TVTAKKSQQH VQHLRALFDY DPEDDVYVPC KELAMKFQRG DILHVLNTKD
DNWWQAYRDG EDIQHSLAGL IPSSSFRQQV VLYADEVERE QEQKRKECKG KKKKKLEVKK
GADEENLPAI GVYSDFLTYE EVVLELPKAT HRRPIVLCGA EGVGCLKLRD RLLESDRITL
ACPVPYTSRT PKEGEFNGVH YHFVSKQKFH EDAKSGKFVE FGEYQKFWYG TAKKDVVNVI
ERGKTCVMTL KAESLGAIRS PDIQPYIIFI AAPSLYILRR QREVEGTFGV KDDELKAILT
QSKSIEQKYG HLFDGIIVNI DFEKSFRELK QILMKVNTEP MWVPATWTAC
//
