ID   A0A3B1IC76_ASTMX        Unreviewed;       831 AA.
AC   A0A3B1IC76;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 3 {ECO:0000256|ARBA:ARBA00020976};
DE   AltName: Full=Component of oligomeric Golgi complex 3 {ECO:0000256|ARBA:ARBA00031339};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000027488.1, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000027488.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Involved in ER-Golgi transport.
CC       {ECO:0000256|ARBA:ARBA00002090}.
CC   -!- SIMILARITY: Belongs to the COG3 family.
CC       {ECO:0000256|ARBA:ARBA00009936}.
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DR   AlphaFoldDB; A0A3B1IC76; -.
DR   Ensembl; ENSAMXT00000031598.1; ENSAMXP00000027488.1; ENSAMXG00000001820.2.
DR   GeneTree; ENSGT00390000015682; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000001820; Expressed in embryo and 14 other cell types or tissues.
DR   GO; GO:0005801; C:cis-Golgi network; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   InterPro; IPR048685; COG3_C.
DR   InterPro; IPR048320; COG3_N.
DR   InterPro; IPR007265; COG_su3.
DR   PANTHER; PTHR13302; CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3; 1.
DR   PANTHER; PTHR13302:SF8; CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3; 1.
DR   Pfam; PF20671; COG3_C; 1.
DR   Pfam; PF04136; COG3_N; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          128..270
FT                   /note="Conserved oligomeric Golgi complex subunit 3 N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04136"
FT   DOMAIN          291..637
FT                   /note="Conserved oligomeric Golgi complex subunit 3 C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20671"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   831 AA;  94551 MW;  555A2CCD3B34D41F CRC64;
     MMKMKPERDG DGERESRTEP RGEERAEERS GWSSLTHKQS ESVEEIRRSA ESLELPSELP
     IEDLCSLPSR SLFPAAIPAS TEDVLLKGFQ MLDMEDRRIE TAQQFFSWFS KLQAQMDQDE
     GAKYRRTREC LSCYQDQCDA ILTDVSAALE HLDSLQKQYL FVSTKTGTLH EACEQLLKEQ
     SELVDLAESI QQKLSYFNEL ENINTKLNSP TLSVNSEGFV PMLSKLDDCI EYVSAHPNFK
     DHPVYLAKFR QCLSKAMQLI RTHAVSTLQN LTSQLTKRDP LGVANADNAF TLYYVKFRAT
     APKLRTLIEQ VEQRSEKIPE YQQLLDDIHQ SYLEQREALL SPSINSTITD LTSQSNKDHC
     ALVRSGCAFM AHVCQDENQL YSEFFSKPTA KLDELLEKLC LSLYDVLRPL IIHVVHLETL
     SELCGILKNE MLEDHVHNNT VQLGAFEAVV KQMLEDVQER LVYRTHIYIQ TDISGYSPAP
     GDLAYPEKLQ MMEKIAQSLK EEQLRLNSPD SSFSDVQLED PESRKLISSG GVESSRVPAS
     VSPADLHGMW YPTVRRTLVC LSKLYRCIDR AVFQGLSQEA LSACIQSLLK ASEDILKNKS
     QIDGQLFLIK HLLILREQIA PFHADFAIKE ISLDLKKTRD AAFKILHPKA VPKFFRLNSH
     NAILEFLLEG TPEIKEHYID SKKDVDRHLK SSCEHFIQQQ TRMFVGSLEE FLTKVAALKT
     MAIQGGPTYN LSQQPWAQPA KINDLVMSMY RVMKNKVPGT LQSMSLYLAN KDTEFILFKP
     VRNNIQQVFQ KLHNVLQEEY SGEDLQIIAC PSMEQVSVVE AYLVMVTGNP G
//