ID A0A3B1ICF4_ASTMX Unreviewed; 332 AA.
AC A0A3B1ICF4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Ring finger protein 121 {ECO:0000313|Ensembl:ENSAMXP00000027250.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000027250.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000027250.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_007247115.1; XM_007247053.2.
DR STRING; 7994.ENSAMXP00000040348; -.
DR Ensembl; ENSAMXT00000038873.1; ENSAMXP00000027250.1; ENSAMXG00000042257.1.
DR Ensembl; ENSAMXT00000050443.1; ENSAMXP00000040348.1; ENSAMXG00000042257.1.
DR GeneID; 103027590; -.
DR KEGG; amex:103027590; -.
DR CTD; 55298; -.
DR GeneTree; ENSGT00390000013075; -.
DR OMA; NPYWERP; -.
DR OrthoDB; 10447at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000042257; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:1903069; P:regulation of ER-associated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0001966; P:thigmotaxis; IEA:Ensembl.
DR CDD; cd16475; RING-H2_RNF121-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR040176; RNF121/RNF175.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13407:SF1; RING FINGER PROTEIN 121; 1.
DR PANTHER; PTHR13407; RNF121 PROTEIN; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 59..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 231..281
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 332 AA; 38505 MW; 61EAF45BAE370707 CRC64;
MAGVFEVEVD GVEHDHGHGP HDEASQIDLS QLSPEEKWRL EHARMHAKHK GHEAMHAEMV
LILIVTLVIA QLVLVQWKQR HPKSYNLVTL FQMWVVPLYF TTKLHWWRFL VTWFIFSVVT
AFITFRATRK PLECTTPRLV YKWFLLLYKI SYTTGIVGYA VVMFTLFGIN LIFRIKPEDA
MDFGVSLLFY GLYYGVLGRD FAEMCADFMA STVGYYSASG MPTKHLSDSI CAVCGQPILV
DVDEEGIMEN TYRLSCNHVF HEFCIRGWCI VGKKQTCPYC KEKVDLKRMF SNPWERPHVM
YGQLLDWLRY LVAWQPVIIG LVQGINYILG LE
//
