ID A0A3B1IDU2_ASTMX Unreviewed; 203 AA.
AC A0A3B1IDU2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Relaxin-3-like {ECO:0000313|Ensembl:ENSAMXP00000028093.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000028093.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000028093.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000256|ARBA:ARBA00011207}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR AlphaFoldDB; A0A3B1IDU2; -.
DR STRING; 7994.ENSAMXP00000028093; -.
DR Ensembl; ENSAMXT00000033550.1; ENSAMXP00000028093.1; ENSAMXG00000039024.1.
DR GeneTree; ENSGT00940000154396; -.
DR InParanoid; A0A3B1IDU2; -.
DR OrthoDB; 4265509at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000039024; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd00101; IlGF_like; 1.
DR CDD; cd04365; IlGF_relaxin_like; 1.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR20968; ILGF DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR20968:SF4; RELAXIN-LIKE PEPTIDE LOCUS B; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..203
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017198541"
FT DOMAIN 36..203
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 95..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 203 AA; 22621 MW; 56ECC95E8827B399 CRC64;
MARARLCWVV LMLGVVLVCG VGVCAGEGAL QRDYGVKLCG REFIRAVIFT CGGSRWRRGV
EQERERIDQD SPFFLSSYQN PFDRNEESIW TQTTTNNNQQ PSFLSSSSSS SSSSPSLSDL
LQAMGEQTQR GPVELDPSED GLRDGGVRTW LDALFPSGRL RKMDISWQHQ QQQADRKKRN
FSLGLAGMCC NQGCTKNDIG RLC
//
