ID A0A3B1IF23_ASTMX Unreviewed; 387 AA.
AC A0A3B1IF23;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Transcription factor GATA-4 {ECO:0000256|ARBA:ARBA00039930};
DE AltName: Full=GATA-binding factor 4 {ECO:0000256|ARBA:ARBA00041505};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000028276.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000028276.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_007238766.1; XM_007238704.2.
DR RefSeq; XP_015458327.1; XM_015602841.1.
DR AlphaFoldDB; A0A3B1IF23; -.
DR STRING; 7994.ENSAMXP00000028276; -.
DR Ensembl; ENSAMXT00000044057.1; ENSAMXP00000028276.1; ENSAMXG00000035495.1.
DR GeneID; 103031262; -.
DR KEGG; amex:103031262; -.
DR CTD; 2626; -.
DR GeneTree; ENSGT00940000158349; -.
DR InParanoid; A0A3B1IF23; -.
DR OMA; GSFPNHY; -.
DR OrthoDB; 685518at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000035495; Expressed in heart and 3 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00202; ZnF_GATA; 2.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 2.
DR InterPro; IPR008013; GATA_N.
DR InterPro; IPR016375; TF_GATA_4/5/6.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; TRANSCRIPTION FACTOR GATA FAMILY MEMBER; 1.
DR PANTHER; PTHR10071:SF154; TRANSCRIPTION FACTOR GATA-4; 1.
DR Pfam; PF00320; GATA; 2.
DR Pfam; PF05349; GATA-N; 1.
DR PIRSF; PIRSF003028; TF_GATA_4/5/6; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 2.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00094}.
FT DOMAIN 184..238
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT DOMAIN 238..291
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT REGION 54..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 40881 MW; 3F4B0A0EDE12D2B8 CRC64;
MYQGLTISAT HHAAHSYEAS FLPSVGSTAR SPVYVPSPRV PAVLPALPYL QAHGAPHHGA
SSSSAHSAWA QDPGSSSSSP PSSYSAGGSG NTAHAPPVSP RFVFSANSPL CSGMTGTLDT
PAGGARGLGM GPSYHPSPYP AYVSPGMGGT WAASHFDSSV LHGLQSGDQN PVARHPDLEL
FDDFAEGREC VNCGAMSTPL WRRDGTGHYL CNACGLYHKM NGINRPLIKP QRRLSASRRV
GLSCTNCQTT TTTLWRRNTE GEPVCNACGL YMKLHGVPRP LAMKKEGIQT RKRKPKNLNK
PKPEPARADG HTPSNASTSG TAAELRPIKT EPDTPTLYSH HNIHTQVTAI PAYVGSQHGA
SSLKLSPGIH AGAHSAKNET WNSLILT
//
