ID A0A3B1IF29_ASTMX Unreviewed; 990 AA.
AC A0A3B1IF29;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Zinc finger protein 217 {ECO:0000313|Ensembl:ENSAMXP00000028160.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000028160.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000028160.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR AlphaFoldDB; A0A3B1IF29; -.
DR STRING; 7994.ENSAMXP00000028160; -.
DR Ensembl; ENSAMXT00000043428.1; ENSAMXP00000028160.1; ENSAMXG00000001689.2.
DR GeneTree; ENSGT00940000159884; -.
DR InParanoid; A0A3B1IF29; -.
DR OrthoDB; 3849084at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000001689; Expressed in zone of skin and 7 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR041661; ZN622/Rei1/Reh1_Znf-C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45925; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR45925:SF4; ZINC FINGER PROTEIN 217; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF12756; zf-C2H2_2; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 118..140
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 146..168
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 203..230
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 392..419
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 483..510
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 511..538
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 226..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 990 AA; 108792 MW; BA184F41463107A3 CRC64;
MPTHPLMPYV ESPDGLGHDI LNHSSATMPG SSSSMTPHIS LAEKTDAQMA QTAGSLPLDC
MFCDQTFQNE EELRPHLFAQ HQTTLHAPAV LRVEAEFLTP GERACSKSCL PTEPEEQLDC
VVCGQATESA AELEAHMRKH KDSFIYSCNM CGRRFKEPWF LKNHMRTHGK SGGRSKNQDT
EAPVTINDVI QEQPQSNAVT AYKMCMVCGF FFLNKEVLAE HSKVHSREAE LSEENVSAES
EPAVESHDSE SHDSESHASK DGFLQYLQLR PASSQESAVQ NQSQSGRWIS HLDPFNTYQA
WQLATKGKIA VGPNLNKELN IDSNSDNDDF GSDKEELGSI WDSSNGDKPV RRGLRNELKP
KFNGRETPSP LPDQKSLIRN SGHNNINNNK PTDCEECGKT FRTYHQLVLH SRVHKKERGG
AESPTTPVEG RAQSVGSSGS PSLDRVEDGS EDGFEEGVAG ESFHSDKGED GSHKMKLKIL
APRKCCYCGK TFRSNYYLNI HLRTHTGEKP YKCDYCDYAA AQKTSLRYHL DRRHKDRPFT
EIPNIPTKGR ESPRNTDDKQ ASKPPKQWPA PSPASAVVKQ EVGPGQPGVI TTASSVIRVK
EECGNMSTTA LYTPSPGEAR VKCLLPNSFK TESKESADAA PLNLSFKVSL SISATSVPRN
LLPTNSCKSC PYETLYPEVL LMHKKLIHKE NLDMKKNGYR PPLKLKRYTG CPPALEGKDV
SPLPHINRRH PRRTKSPPPP PQAGRSVEKV QPQKPPQILK VSPAKEPRRD HHLQGTQRIK
LPEGSIASIA SIPPRFPDVA VDPGRKLNSP AVVDRGTSNQ KPAPSSRTSV IWPSDVARLC
LSDRFRSLTQ MDYGEPSSKR LKPAEPLQGA GRIGDEFSRL VPSGRNVKSV LQGNLPFAPV
RVAPSVPSGG SGSSVEADWN VINLLRSYTP SDLAPLYQPV VAGSAHTPGN SPSAGSRPLV
LPHYSASISQ RRNHQSSLPN SRPAPPDASS
//
