ID A0A3B1IG64_ASTMX Unreviewed; 1593 AA.
AC A0A3B1IG64;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Alsin Rho guanine nucleotide exchange factor ALS2 b {ECO:0000313|Ensembl:ENSAMXP00000028550.1};
GN Name=ALS2 {ECO:0000313|Ensembl:ENSAMXP00000028550.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000028550.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000028550.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSAMXT00000052651.1; ENSAMXP00000028550.1; ENSAMXG00000005016.2.
DR GeneTree; ENSGT00940000155861; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000005016; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd13269; PH_alsin; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR46089:SF3; ALSIN; 1.
DR PANTHER; PTHR46089; ALSIN HOMOLOG; 1.
DR Pfam; PF02493; MORN; 7.
DR Pfam; PF00415; RCC1; 4.
DR Pfam; PF02204; VPS9; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00698; MORN; 7.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00626; RCC1_2; 2.
DR PROSITE; PS50012; RCC1_3; 5.
DR PROSITE; PS51205; VPS9; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT REPEAT 25..74
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 75..133
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 134..184
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 474..525
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 526..576
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 646..832
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1449..1593
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 232..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1381..1405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1382..1396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1593 AA; 175023 MW; 2FEF2A3FE8840958 CRC64;
KVLLSRPVLQ AALGAKHGVL LVEGGQVYSF GELPWKQNQP SSGTTEPLLE AGLSEQHVVC
VAAGASHSGA VTEDGVVHMW GDNTYGQCGL SGLSVVPNPT PVAVVDCEAT PPQPIRVLEV
ACGEQHTLAL SARHEVWSWG SGCQLGLLTT TFPVWKPHKV EHLAGRHVLQ VVCGASHSLA
LVRCLPPPQE ARRLPADKCG QCNQSLYTMT DKEDHVIISD SHYCPLGVEL EDGDSKSGSE
GSLGLGKMKS SPSEPILSAY TQSPKSVIPL SSSPGATSVS APAPVSETQG QTPRTESQPV
LADGVVSGAA PQSQTSETDS TEARASAELT ASSDVFISDP STPVAQSVTP MGSALNHLVV
SCASAVGERV ASTYEALSLR KVINYWVTAK KHDRERPEER VRQEEHRQGK KSCSLGDIRE
EEAEGLSRRL SLPGLLSQVS PRLLRRVSRP PVRAVALTPV GVAESDAHLP SLQTEVWSWG
RGQEGQLGHG DLLPRLQPLC IKSLSGKEVI RVAAGALHSL ALTAQSEVYS WGSNSFGQLG
HMESPSTIPR LAKLSDGIRA WDVGAGQHHT LLLADGDCFQ PILYYSGQQV KEGSAESTQE
QTGGYTQQPV LLPFCMNLGY VSSVCAGGQS CAALADRNVM GFIGSLHELA AAERKYYCKL
TSIKSVLLQP LSALGPACTG LLQNLISRFG RLAQLTGQNS ASLTSFLRRS RDVRGLVLLE
NAQLFLDTYS EYCASVGNLL VMGGFQALVR PCQDVFGKGA EVVQKLSEGC EDGAMLADIL
SHLFYLPVRH LHEYGHLLLK LATCYEVNSM DYQKLQDVCS KYESLVLLLK RKRKEAEYTL
HFWKSFPGKM TDSLRKPSRR LVCESSNKAL TLQNAGRFSV NWFILFNDAL VHAQFSTHHV
FPLATLWVEP VSEENAGLYG LKVTSPEESF TLLASSPSEK AKWLRSINQA VEQALSGTGM
DTSGAAMRAD PPISRTASYT FYKDSRLKEV MYEGRWLAGK PNGRGVLKWP DGRMYTGTFK
NGLEDGYGDY IVPNKNLNKS DHYQGHWKDG KMHGFGNFRY ATGELYEGSF QDNMRHGHGM
LRSGKLNSTS PSVFIGQWLH DKKTGYGVFD DITRGEKYMG LWQEDLRQGN GVIVTQFGLY
YEGAFSNNKM MGTGVLLSED DTTFEGDFSD DWTLSGKGTL TMPNGDYIEG SFSGVWGTGL
KISGSYYKPN LYDSDKDKNR TKLGRLAVPS EEKWKAVFGE CWSRLGCESP GQGDTSTAWD
NIAIALTTNR RQHRDSPELL SRSHNKTLES LEFIPQHVGP VTLEKYHIIR RYLIKACDTP
LHPLGRLVET LVAVYRMTYV GVGANRRLLQ QAVNEIKSYL SRIFQIVRFL FPDLPEEGGL
LAEGPNEKKE SESSGNKIDS PKPGRVVSSS ALLLPVLLPR LYPPLFTLYA LEKEKEDDVY
WECVLRLNKQ PDLALLAFLG VHQKFWPVTM TLHGEKQQVL SSTKDACFAS AVETLQQIST
TFTPSDKLQV IQLTFEEITQ EVLALLKQDF LWSMDDLFPV FLYVVLRARI RNLGSEVSLI
EDLMDPCVQH GEHGIMFTTL KACYYQIQHE KIT
//
