ID   A0A3B1IG82_ASTMX        Unreviewed;      1005 AA.
AC   A0A3B1IG82;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000028922.1, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000028922.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC       IAN subfamily. {ECO:0000256|ARBA:ARBA00008535}.
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DR   AlphaFoldDB; A0A3B1IG82; -.
DR   Ensembl; ENSAMXT00000040996.1; ENSAMXP00000028922.1; ENSAMXG00000030535.1.
DR   GeneTree; ENSGT00500000044904; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000030535; Expressed in zone of skin and 9 other cell types or tissues.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   CDD; cd00882; Ras_like_GTPase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR006703; G_AIG1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR   PANTHER; PTHR32046; G DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR32046:SF14; IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE; 1.
DR   Pfam; PF04548; AIG1; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR   PROSITE; PS00675; SIGMA54_INTERACT_1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN          43..174
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          504..671
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   COILED          269..306
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          890..920
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1005 AA;  116282 MW;  725DDAF351548D0C CRC64;
     MKKSTEVSSG PPAVRRLFTT RSNLDESGKI RKWIFGQQNV NMQNKTILLV GETGTGKTTL
     INTMVNYYLG VKFEDNVWFE ITEEETRDQT ESQTSEITVY EIFSEQKPES LTIIDTPGID
     KDMKIPQNLY KLFLHETGVK SLDAVCLVLK SSQNRISERL RYIFDAILAL FGKDLERNVV
     LFITHTDRFT VDVLEAVEKE KILCCHDAEN EPVHFLFNNI QSVMQTAKTK RTIKSAWEMG
     QSSMKRFLDF LKSRQRKGLT MSVSVLKERM QLEDCIQNLK EQIEFMEETE KELSEMQNLL
     KLKKEKVEKD NDFHFTVNIV YTEKPAFNTQ LCYVMNDENC TVCKCHSTKH VKEARKHVTK
     QEEEPEDEKL EKKEELTDVE ISLKTLLTKN EKKKNILLKD ASELIMKLSK TPDSPLTLCY
     LDFLIPRVEE AGEEEWAQKL KDLQKRKISS FNNESSAIND LMQKSTELSS GPPAVRRLLT
     TRSNLDESGK IRKWTFGQKY ANMKNKTILL VGETGTGKTT LINTMANYYL GVKFEDKVWF
     EITEEEKCQT ESQTSEITVY EIFSEQKSFS LSIIDTPGYG DTRGIEKDVE ILLNLCNLFL
     HETGVKSLDA VCLVLTASQN RISERQCYIF NGALSLFGKD AMDIIVFFIT HSDGLPPKDV
     LESVEKEKIP CCHDAENQPV HFLFNNRQFQ KHTAKNKRAV KMDWEMGEKS LEEFFEFLKS
     SERKSLTMTV DVLQERKQLE ACVQSWQECI EFIEVKQREL TEVQNALIQN KEQIEKDINH
     LFTVRRVYKE KVDITDASWW DEKATSCDVC KKNCHEFGCW RSPTVWWCEI ISDNKCKVCG
     CHYTTHTREA KKYVTKEKSE TVTFEELKNK YINTNAENIT YDKSAFNTVK TEHEKKLKRK
     EELMNQESSL TELLAKKEKE KNSSVKEAYE AIIKLSEIAL KPDSAFTLQY LEFLIPRVEE
     AGEAEWAQKL KDLQKDAAKE STTYAVGYLN SMKGFFSGKG FVSKQ
//