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Database: UniProt
Entry: A0A3B1IGP1_ASTMX
LinkDB: A0A3B1IGP1_ASTMX
Original site: A0A3B1IGP1_ASTMX 
ID   A0A3B1IGP1_ASTMX        Unreviewed;       810 AA.
AC   A0A3B1IGP1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000029077.1, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000029077.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000256|ARBA:ARBA00007367,
CC       ECO:0000256|RuleBase:RU003722}.
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DR   AlphaFoldDB; A0A3B1IGP1; -.
DR   Ensembl; ENSAMXT00000035453.1; ENSAMXP00000029077.1; ENSAMXG00000005215.2.
DR   GeneTree; ENSGT00940000156807; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000005215; Expressed in olfactory epithelium and 1 other cell type or tissue.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   Gene3D; 6.10.250.2020; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004709; NaH_exchanger.
DR   InterPro; IPR032103; NHE_CaM-bd.
DR   NCBIfam; TIGR00840; b_cpa1; 1.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF89; SODIUM/HYDROGEN EXCHANGER 2; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF16644; NEXCaM_BD; 1.
DR   PRINTS; PR01084; NAHEXCHNGR.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU003722};
KW   Ion transport {ECO:0000256|RuleBase:RU003722};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Signal {ECO:0000256|SAM:SignalP}; Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU003722};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003722};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003722}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..810
FT                   /note="Sodium/hydrogen exchanger"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017425837"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        93..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        122..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        157..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        196..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        223..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        265..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        307..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        351..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        446..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          72..470
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   DOMAIN          564..668
FT                   /note="Sodium/hydrogen exchanger regulatory region"
FT                   /evidence="ECO:0000259|Pfam:PF16644"
FT   REGION          20..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          681..810
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..48
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..736
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        737..761
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   810 AA;  91180 MW;  3E034343C26C29DB CRC64;
     MDRIDAGILL ALLSFGANAE DSPKPTTTKP PAKPTEHGPI YTAPPQPLPE PEKSYLPLFT
     LNYPRVQIPF EITLWVLLAS FAKIGFHVYH KITIWVPETC LLISIGLIVG AIMHSVHEQP
     PAVLTSSVFF LYMLPPIVLD SAYFMPTQPF FENVGTVLWF SIVGTLWNSI GVGICLYGVC
     QIPALGVQDI NLQENLLFAS IISAVDPVAV LAVFEDVNIN EQLYIVAFGE SLFNDAVTVV
     LYNLFNHVAE LPVVDAADVF LGVLRFFLVG LGGMLFGLVF GFVAAFTTRF TRKVREIEPL
     FIFMYSYLAY LLAELLSISS IMAIVTCALT MKYYVEENVS QRSCTTIRHV IKMLGTVSET
     LIFFFLGVVT ITTDHEWNWG YILFTILFAQ IWRGLGIVVL TQIINPFRTI PFNFKDQFGL
     SYGGLRGAIT FALAYTLPNT IIRKKLFITA TIAIIIFTVF IQGISIRPII ELMNVRKTNW
     KLGTINVEIH TRLMEHITAG VEDLCGQWSH HSLKDKFMRF NNRFIRKILI RDNRPESSIV
     ALYKKLELQN AMEVLDTISG DISAAPSLIS MHEEKASNKS SFKPKRTFLA SDLTAMHEIL
     SKNMYKIRER TMSYTNKHTL PNDSRAREIL VRRHTSIRRS LRARSFQGSE SARSQKYFSL
     PLGQSLDTGY ATESIRLNAD GDPALELHNR SVRPKPRPRS KQPRFSTTRA RLDPLQELHS
     TVNMEDEVRA EESSHRPSRQ SSSSSNSRSR APLQRHSSLG TPSVGEDDPE GDEQQLESPP
     PAWTPEPPDR GSGGPRNPLL RRAQWKPQDK
//
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