ID A0A3B1IGP1_ASTMX Unreviewed; 810 AA.
AC A0A3B1IGP1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000029077.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000029077.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|ARBA:ARBA00007367,
CC ECO:0000256|RuleBase:RU003722}.
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DR AlphaFoldDB; A0A3B1IGP1; -.
DR Ensembl; ENSAMXT00000035453.1; ENSAMXP00000029077.1; ENSAMXG00000005215.2.
DR GeneTree; ENSGT00940000156807; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000005215; Expressed in olfactory epithelium and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR Gene3D; 6.10.250.2020; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004709; NaH_exchanger.
DR InterPro; IPR032103; NHE_CaM-bd.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF89; SODIUM/HYDROGEN EXCHANGER 2; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF16644; NEXCaM_BD; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU003722};
KW Ion transport {ECO:0000256|RuleBase:RU003722};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}; Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003722}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..810
FT /note="Sodium/hydrogen exchanger"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017425837"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..470
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 564..668
FT /note="Sodium/hydrogen exchanger regulatory region"
FT /evidence="ECO:0000259|Pfam:PF16644"
FT REGION 20..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..48
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..736
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 810 AA; 91180 MW; 3E034343C26C29DB CRC64;
MDRIDAGILL ALLSFGANAE DSPKPTTTKP PAKPTEHGPI YTAPPQPLPE PEKSYLPLFT
LNYPRVQIPF EITLWVLLAS FAKIGFHVYH KITIWVPETC LLISIGLIVG AIMHSVHEQP
PAVLTSSVFF LYMLPPIVLD SAYFMPTQPF FENVGTVLWF SIVGTLWNSI GVGICLYGVC
QIPALGVQDI NLQENLLFAS IISAVDPVAV LAVFEDVNIN EQLYIVAFGE SLFNDAVTVV
LYNLFNHVAE LPVVDAADVF LGVLRFFLVG LGGMLFGLVF GFVAAFTTRF TRKVREIEPL
FIFMYSYLAY LLAELLSISS IMAIVTCALT MKYYVEENVS QRSCTTIRHV IKMLGTVSET
LIFFFLGVVT ITTDHEWNWG YILFTILFAQ IWRGLGIVVL TQIINPFRTI PFNFKDQFGL
SYGGLRGAIT FALAYTLPNT IIRKKLFITA TIAIIIFTVF IQGISIRPII ELMNVRKTNW
KLGTINVEIH TRLMEHITAG VEDLCGQWSH HSLKDKFMRF NNRFIRKILI RDNRPESSIV
ALYKKLELQN AMEVLDTISG DISAAPSLIS MHEEKASNKS SFKPKRTFLA SDLTAMHEIL
SKNMYKIRER TMSYTNKHTL PNDSRAREIL VRRHTSIRRS LRARSFQGSE SARSQKYFSL
PLGQSLDTGY ATESIRLNAD GDPALELHNR SVRPKPRPRS KQPRFSTTRA RLDPLQELHS
TVNMEDEVRA EESSHRPSRQ SSSSSNSRSR APLQRHSSLG TPSVGEDDPE GDEQQLESPP
PAWTPEPPDR GSGGPRNPLL RRAQWKPQDK
//