ID   A0A3B1IGS8_ASTMX        Unreviewed;      1153 AA.
AC   A0A3B1IGS8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Folliculin interacting protein 1 {ECO:0000313|Ensembl:ENSAMXP00000029112.1};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000029112.1, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000029112.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004656}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the FNIP family.
CC       {ECO:0000256|ARBA:ARBA00007541}.
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DR   AlphaFoldDB; A0A3B1IGS8; -.
DR   Ensembl; ENSAMXT00000048781.1; ENSAMXP00000029112.1; ENSAMXG00000000950.2.
DR   GeneTree; ENSGT00390000009391; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000000950; Expressed in heart and 14 other cell types or tissues.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR037545; DENN_FNIP1/2.
DR   InterPro; IPR028086; FNIP_C_dom.
DR   InterPro; IPR026156; FNIP_fam.
DR   InterPro; IPR028085; FNIP_mid_dom.
DR   InterPro; IPR028084; FNIP_N_dom.
DR   PANTHER; PTHR21634:SF12; FOLLICULIN-INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR21634; UNCHARACTERIZED; 1.
DR   Pfam; PF14638; FNIP_C; 1.
DR   Pfam; PF14637; FNIP_M; 1.
DR   Pfam; PF14636; FNIP_N; 1.
DR   PRINTS; PR02073; FOLLICULNIP1.
DR   PROSITE; PS51836; DENN_FNIP12; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN          36..1144
FT                   /note="UDENN FNIP1/2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51836"
FT   REGION          11..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          99..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          569..598
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          645..665
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          904..947
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        576..594
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1153 AA;  128090 MW;  2CDD254A3C9C971E CRC64;
     MPPTLFQKLF NKRGPLSPPP RSSTEDPALS WPSSELELGQ IRLIVYQDCE RRGRNVLFDS
     NSKKKSAEDA SVTKMCGQSQ AKMFGKCCQL RPLGGSSSSL DSSSSCASEP REHNRFQGTP
     HCSSDANMLG EMMFGSVAMS YKGSTLKIHQ IRSPPQLMLS KVFTARTGSS VYGSLNTLQD
     SLEFISQDSN TLRPDQGTVV NGFLGNIGHS NPMDMPGRGL YDERDSGIAR SASLSSLLIT
     PFPSPGSSLT SSCASSYQRR WLRSQTTSLE NGVFPRWSVE ESFNMSDENS GPSLGITRKK
     KIAIGVIFLL SPNEEENSKF QDFFFSHFPL FESHMNKLKS AIEQAMKMSR RSADVSQRVL
     AHSRIVDGLN EFRTTICNLY TMPRVTEPVW LTMMSGAPEK NQFCGQFIRE LAFLMEQASK
     NQFLPALLTA VLTNHLAWVP TVMPNGQPPI KIFLEKHSSQ SVDMLAKTHP YNPLWAQLGD
     LYGAIGSPVR LARTVVVGRR QELVQRLLYI LTYFIRCSEL LETHLLESAE DEAIVMPGSL
     ITTSLRRGEV EESDYVLVTM HKPNHDYLSQ GAEAEDGYPS DSNSLQSSTY TDTELGLGVP
     EDQLPEQRLQ HVIPVIRAED HSDGPTFREV GSPRPDARLE TMVKVGSTSP RESGPFVDIE
     GQSEKPDVEV SSLSIKMFRS SGIPLEKKPP DKSLASTSFL LDEEEEPAAK VTFLIGDSMS
     PESDMESRQG KVEEEFNRHR NRHFDEEQQQ PCRSVQQGRA KALLSKPLST DQIRNNKSKE
     AKPFARIAGD IPHISPETQE DCMDLFDEYF SEENPVETMT IDDVSVKALE TAANGVDKLH
     KCGQTSSRVG SLVGTHEQVC VQREGGQCKC STSSTTTIGG YTSCYFAEQD KSIGISLSVP
     SQRDIGEQKK VPPLNDWEIP RNESSDSALG DSESEDAGQE LPRQEQDEQF FSEELAEWQD
     ELEVPFPGAK LVENYSKPSI ANFGRSLFGG YCPTYVPDFV LHGIPNDDKL RQSLVSDLSH
     AVQHPVLDEP IAEAVCIIAD TDRWTVQVAS SQRRATENKL GKEVLVSNLV SNLLQSTYQL
     YRLNLSPNFC IMHLEDRLQE LYFKSKMLAE YLKGQTRVHV KELGMVLGIE SSDLPLLAAI
     ASTHSPYVAQ ILL
//