ID A0A3B1IH57_ASTMX Unreviewed; 262 AA.
AC A0A3B1IH57;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Origin recognition complex subunit 6 {ECO:0000313|Ensembl:ENSAMXP00000028579.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000028579.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000028579.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ORC6 family.
CC {ECO:0000256|ARBA:ARBA00010840}.
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DR AlphaFoldDB; A0A3B1IH57; -.
DR STRING; 7994.ENSAMXP00000028579; -.
DR Ensembl; ENSAMXT00000031007.1; ENSAMXP00000028579.1; ENSAMXG00000029855.1.
DR GeneTree; ENSGT00390000007370; -.
DR InParanoid; A0A3B1IH57; -.
DR OrthoDB; 2899737at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000029855; Expressed in olfactory epithelium and 11 other cell types or tissues.
DR GO; GO:0005664; C:nuclear origin of replication recognition complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd16075; ORC6_CTD; 1.
DR CDD; cd11583; Orc6_mid; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 1.
DR InterPro; IPR008721; ORC6.
DR InterPro; IPR020529; ORC6_met/pln.
DR PANTHER; PTHR13394; ORIGIN RECOGNITION COMPLEX SUBUNIT 6; 1.
DR PANTHER; PTHR13394:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 6; 1.
DR Pfam; PF05460; ORC6; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT REGION 185..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 262 AA; 29020 MW; 6C7E8B075A3916F2 CRC64;
MDKELFRKLA SKMGISSVRV LSQAEEYMRL SQVRCTSLGG ATATSKAIIC LELAATAMKF
PLDKEFAIKL SGLNKKIYQS SLKSMECMLG LQSGVGLREL AVQYGCMEAV KVASQILQRY
GASLPAAQQQ DLDLSKPLFT TAALFTACKC MKIRADKKLA SSSGAKKGIF DRLCSQLQKF
GQEICSSAPS MKGPPKTTQK RQKTLTETLQ ETEEDDGLPT SPKQQREQQL RDDEAEEDPR
QNYEEWKRKI LENAMRATPG DS
//
