ID A0A3B1IJ75_ASTMX Unreviewed; 618 AA.
AC A0A3B1IJ75;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Docking protein 3 {ECO:0000313|Ensembl:ENSAMXP00000029937.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000029937.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000029937.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1IJ75; -.
DR STRING; 7994.ENSAMXP00000029937; -.
DR Ensembl; ENSAMXT00000033117.1; ENSAMXP00000029937.1; ENSAMXG00000032345.1.
DR GeneTree; ENSGT00940000155980; -.
DR InParanoid; A0A3B1IJ75; -.
DR OrthoDB; 2996885at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000032345; Expressed in mesonephros and 1 other cell type or tissue.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR21258:SF14; DOCKING PROTEIN 2; 1.
DR PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR Pfam; PF02174; IRS; 1.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 146..250
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 119..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..331
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..489
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 618 AA; 67570 MW; 75E384C24259DFDF CRC64;
MDVVAKEGSL FLQGVKFGKR IWRKTWVILF QPTAMGIGRI EMYDIRDGGG GAKPTGLKKA
DKRVVRLTDC LSITPAPGES CPSGCAAFYL NTTQRTYTLA NPLQDEWVPT LCQLAFQRSE
GGGDSRRAQR DDDTSMSEND LYSTWSPGKF QVTVQKSDAS VRCCMSGSYL LSPEKEALCL
LDLRTGKTVF YWPYRFLRRF GQIKEGVTIE AGRRCQTGEG HFAFLSKQGT QIYRAIEEAI
MHQSVQDLLS KATAEVKELT TQQLPVRPAI NDLAKATQGS PTRGVHDRPY PVPSRRNLAL
PAPPVPTPPV PLTSQAPPVP PAPPAPPATF NKPSAIVPKR VAVRNKPLPS ASNFQTSASK
PQTSVSNFQT SASKPQTSVS NFQSNPSKPQ TSPSKPQMSA SNLPISASNF LTSASNFQTS
AGKPQKSASK PQMSVSNLPT SSSKPPTSTN TTEEVLYATI QPQPKPRVKP APPKIPQFPV
TPSYSPPQPK QKWEPQKETK DYNSSPSDED PDSDYCNWKQ GSEMCQDTPN IEDLYSIVVP
PPRNRTKQNT EASQDQAEPS HNTAASSPSD MQANFKQMLS NVLFKDLARI TPSGSYGGSS
DHLAKLDLDD MDYCDIPK
//
