ID A0A3B1IJL1_ASTMX Unreviewed; 563 AA.
AC A0A3B1IJL1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Complement receptor type 2-like {ECO:0000313|Ensembl:ENSAMXP00000029434.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000029434.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000029434.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR AlphaFoldDB; A0A3B1IJL1; -.
DR Ensembl; ENSAMXT00000049867.1; ENSAMXP00000029434.1; ENSAMXG00000031966.1.
DR GeneTree; ENSGT00940000163310; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000031966; Expressed in zone of skin and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 7.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 8.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR19325:SF549; BETA-2-GLYCOPROTEIN 1; 1.
DR PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR Pfam; PF00084; Sushi; 8.
DR SMART; SM00032; CCP; 8.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 8.
DR PROSITE; PS50923; SUSHI; 7.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..563
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017463759"
FT TRANSMEM 521..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..104
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 105..162
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 163..223
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 224..281
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 282..341
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 342..402
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 461..521
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 165..208
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 194..221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 312..339
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 344..387
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 373..400
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 563 AA; 62269 MW; D27BF526D4BF846D CRC64;
MLCNTFLLLL FLLKAVNIRG GTTAVPELLS TQNPPESTTT SAQCQRPTLP DKVILKADSY
KEIYEKDSTA KLECEPGYTP ATFVSRTIKC LGGIWTETKF RCKKKSCGAL KDIPNGRYLI
TEGIEFGAVV KAECNLGYEL YGSDTRVCKL NGWTGRDIEC EVVKCTEVPT IANGKPEEEP
YSQYEFGQSI SYRCNKDFDM FGDSTITCSK DGKFQPAPPE CLKISCARPE IPDATRTEGR
SPYRYKSTVR YECNRGYKMN GEGYLVCQKD GWVPPPPNCT MVTCPKPSVF DNGYFSPDKE
LYKYEEKLTF SCKKGFRLEG ASEIVCTMDE IFKPPPPRCV VVTCPTPQSI SNGRINDPIL
NIYNYGQTVT YSCMEGFRLR GESRLSCIET GKFHPNPPTC VRTCPGPPVI ANGEFDPVLV
RYDSGQAVTY SCIKGFRLQG ASKVSCSEEG TFKPNPPECV ETCPTPPTIS NGEFDPHLKQ
YDQGQKVTYS CPVGYRLNGF STIICSKGGK YHPPPPTQCE LHWGAIAIFT TTPLALLALG
GALFLRNKKN AGKVAVKTEE DGL
//
