ID A0A3B1IKU4_ASTMX Unreviewed; 1030 AA.
AC A0A3B1IKU4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Platelet endothelial aggregation receptor 1 {ECO:0000313|Ensembl:ENSAMXP00000030170.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000030170.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000030170.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3B1IKU4; -.
DR STRING; 7994.ENSAMXP00000030170; -.
DR Ensembl; ENSAMXT00000041346.1; ENSAMXP00000030170.1; ENSAMXG00000018680.2.
DR GeneTree; ENSGT00940000155333; -.
DR InParanoid; A0A3B1IKU4; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000018680; Expressed in heart and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00055; EGF_Lam; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 4.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24052; DELTA-RELATED; 1.
DR PANTHER; PTHR24052:SF12; PLATELET ENDOTHELIAL AGGREGATION RECEPTOR 1; 1.
DR Pfam; PF00053; Laminin_EGF; 5.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00180; EGF_Lam; 13.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00022; EGF_1; 11.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS51041; EMI; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1030
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017415343"
FT TRANSMEM 753..776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..104
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 141..176
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 229..258
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 271..301
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 309..344
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 398..433
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 570..605
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 657..692
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 166..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 248..257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 291..300
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 334..343
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 423..432
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 595..604
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 682..691
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1030 AA; 111226 MW; BB70BBE7A4CAEB6F CRC64;
MKLLWSCVVL FLLGCVCDLT LCLDPRDPNV CSLWESFTTS VKESYAQPFD QVYEEPCSEP
WRANTCTRHR ITYKTAYRQT VKIDYRRRYQ CCPGYYESRN KCVARCTKEC VHGRCVAPDR
CQCEGGWRGD DCSSACDDLH WGPDCSKLCQ CQNGGQCDVV SGSCLCSPGF TGTHCQDRCP
KGFFGQGCLQ QCQCGTGGSC NTTTGECVCR ERVTGTLCDE PCLKSRRCRP RCSCQNGGIC
LGKGVCLCPP GWTGPVCTER CAEGRFGANC AKECLCHNGG HCDPEIGQCQ CAAGFTGERC
KEECAVGSYG QDCKGVCDCA NGARCYHIHG GCLCEPGFSG PQCSQRMCAE GAFGMHCEHS
CLCSPQHTHS CHPLKGECTC QPGWAGLYCN ETCAHGYFGN GCLQPCLCVN GGVCDVVSGV
CNCAPGYTGT HCEKDCETGF YGKECSSKCT CKNAIACSPI DGTCFCKEGW RGPDCSIPCS
EGSWGPGCNA SCQCANGAGC DPADGSCTCT AGWSGALCDQ PCPVGTYGPG CQHRCDCVHY
RGCHSVTGQC LCLPGWTGPR CTEQCPDGSW GHQCNQSCSC LNSASCLPHS GTCLCKPGYW
GPQCQHVCSP GVYGEKCSQK CPSCVHSTSC HHITGQCLCL SGYTGPLCEQ ACPVGYYGKQ
CSGVCRCANN ATCHYQDGSC HCLPGWAGAD CSVLCKAGTF GTNCAQTCSC LPNHLCDPHS
GECVCEPGPG MDCKQERVVS VMMPVSPVER DSWGAIAGIV VLVMLVVLLL ALLLLYRRRQ
KDKQSNTPTV SFSSTRTVNS EYAVPDIPHS YHHYYSNPSY HTLSQNRPPL PHVPNNQDRV
IKNTNKQLFC SLKNMERERR GLFGVDTNAT LPADWKHQEP PKDQGAFGID RSYSYSASLG
KYYNKQLKDS CVAVSSSSLN SENPYATIKD LPGLPLCPPE SSYMEMKSAV PHERSYTEIN
PPALPSTSIS SRGNPHSTPF ICNKKELRSE FTIVRSQKSN GELQSRDMNY SFLSAATDVR
AALSLVSSLA
//
