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Database: UniProt
Entry: A0A3B1IL93_ASTMX
LinkDB: A0A3B1IL93_ASTMX
Original site: A0A3B1IL93_ASTMX 
ID   A0A3B1IL93_ASTMX        Unreviewed;       784 AA.
AC   A0A3B1IL93;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Pendrin {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Sodium-independent chloride/iodide transporter {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Solute carrier family 26 member 4 {ECO:0000256|RuleBase:RU362052};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000030325.1, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000030325.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Sodium-independent transporter of chloride and iodide.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
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DR   AlphaFoldDB; A0A3B1IL93; -.
DR   STRING; 7994.ENSAMXP00000030325; -.
DR   Ensembl; ENSAMXT00000055754.1; ENSAMXP00000030325.1; ENSAMXG00000043653.1.
DR   GeneTree; ENSGT01070000253775; -.
DR   InParanoid; A0A3B1IL93; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000043653; Expressed in camera-type eye and 9 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF33; PENDRIN; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|RuleBase:RU362052};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        95..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        182..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        213..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        258..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        343..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        380..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        414..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        442..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        473..498
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          529..733
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
FT   REGION          609..632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   784 AA;  86190 MW;  41BADEBA201BFD42 CRC64;
     MYTIMNRYSV SRPIYSKRAF EEDNERQTPE SRSFREKISI FLTCSSSRAK QVLKGLFPIL
     DWLLQYPVKL WLPSDVISGV STGLACCLQG LAYALLVYVG PVYGLYAAFF PVLPYFFLGT
     SRHLSVGPFP VTCLMVGSEV LALAPDEEFM LPGNGTSVNE TGLVSVAMEV DVNARDSQRV
     TIASTMTVLI GLFQLGMGIL HVGFLVRYLS DPLVGGFTTA AAFHVLISQL SLVLSVPTKS
     HSGFLSFAYI LNDVFQNIWQ TNVADLVAGL LTILIVMAVK EVNAKFEHKI PVPIPIEVIV
     TVIATGISYA VDLRSHYGAS IVHSIPRGFV PVQRPKIELF GRIIRSSFST AVVGYAIAVS
     VAKLYETKHD YKIDGNQELI AFGISNIFCG CFSGFVATTA LSRTAIQEST GGKTQMAGLI
     SALIVLIVIV ALGPLLQPLQ KSVLAGIVIA NLKGMFMQIS DVPILWKQSR TDCFIWVFTC
     ISCIILGLDV GLLTGVVFEL GTVVVRSQFP SCSTLGNVPG TEIYRSIKNY KNIVEITGIK
     IFKCNSPIYF ANMDYVKEQL RDAVGFDAIR VFKKRNKALK KIHKLVKKGK LKFTENGLVP
     VAHMGVDNDA FDRERDPEQT ESGPSEEMEG GPRRDIEVEV QVDWTSALPV DVTVPKVDIH
     SLVMDFSAVS FLDVKSAASL RLVVKEFMRI GVRVYIAGCD DETVRKMEAL CFFDDMVTKD
     MLFLTVHDAV LSIKLEVSNG NVSDPMVDKA SCNETNGCIK LTECCTLVLC NIQKVSRFIL
     SIHK
//
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