ID A0A3B1IL93_ASTMX Unreviewed; 784 AA.
AC A0A3B1IL93;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Pendrin {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Sodium-independent chloride/iodide transporter {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 4 {ECO:0000256|RuleBase:RU362052};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000030325.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000030325.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Sodium-independent transporter of chloride and iodide.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR AlphaFoldDB; A0A3B1IL93; -.
DR STRING; 7994.ENSAMXP00000030325; -.
DR Ensembl; ENSAMXT00000055754.1; ENSAMXP00000030325.1; ENSAMXG00000043653.1.
DR GeneTree; ENSGT01070000253775; -.
DR InParanoid; A0A3B1IL93; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000043653; Expressed in camera-type eye and 9 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF33; PENDRIN; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 95..118
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 182..206
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 213..238
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 258..279
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 343..365
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 380..402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 414..436
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 442..466
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 473..498
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 529..733
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 609..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 86190 MW; 41BADEBA201BFD42 CRC64;
MYTIMNRYSV SRPIYSKRAF EEDNERQTPE SRSFREKISI FLTCSSSRAK QVLKGLFPIL
DWLLQYPVKL WLPSDVISGV STGLACCLQG LAYALLVYVG PVYGLYAAFF PVLPYFFLGT
SRHLSVGPFP VTCLMVGSEV LALAPDEEFM LPGNGTSVNE TGLVSVAMEV DVNARDSQRV
TIASTMTVLI GLFQLGMGIL HVGFLVRYLS DPLVGGFTTA AAFHVLISQL SLVLSVPTKS
HSGFLSFAYI LNDVFQNIWQ TNVADLVAGL LTILIVMAVK EVNAKFEHKI PVPIPIEVIV
TVIATGISYA VDLRSHYGAS IVHSIPRGFV PVQRPKIELF GRIIRSSFST AVVGYAIAVS
VAKLYETKHD YKIDGNQELI AFGISNIFCG CFSGFVATTA LSRTAIQEST GGKTQMAGLI
SALIVLIVIV ALGPLLQPLQ KSVLAGIVIA NLKGMFMQIS DVPILWKQSR TDCFIWVFTC
ISCIILGLDV GLLTGVVFEL GTVVVRSQFP SCSTLGNVPG TEIYRSIKNY KNIVEITGIK
IFKCNSPIYF ANMDYVKEQL RDAVGFDAIR VFKKRNKALK KIHKLVKKGK LKFTENGLVP
VAHMGVDNDA FDRERDPEQT ESGPSEEMEG GPRRDIEVEV QVDWTSALPV DVTVPKVDIH
SLVMDFSAVS FLDVKSAASL RLVVKEFMRI GVRVYIAGCD DETVRKMEAL CFFDDMVTKD
MLFLTVHDAV LSIKLEVSNG NVSDPMVDKA SCNETNGCIK LTECCTLVLC NIQKVSRFIL
SIHK
//