ID A0A3B1ILP6_ASTMX Unreviewed; 1904 AA.
AC A0A3B1ILP6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|RuleBase:RU364134};
GN Name=MED13L {ECO:0000313|Ensembl:ENSAMXP00000030149.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000030149.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000030149.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSAMXT00000038166.1; ENSAMXP00000030149.1; ENSAMXG00000009206.2.
DR GeneTree; ENSGT00390000013680; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000009206; Expressed in olfactory epithelium and 14 other cell types or tissues.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF1; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13-LIKE; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 1129..1456
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1492..1893
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 70..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1288..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1743..1773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..800
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1256
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1288..1336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1904 AA; 206812 MW; D1C66519D33552B8 CRC64;
MSDPAVRKLM EEWSHFYPMV LKRKENERDE SNPTYDSHSH VALEVIVGGV RMIYPAAFVL
VAHADLPVEQ PPPAQGAQSG TRDSSNCGIP LTPPTSPEQP CSGDSGFQTA VSSVASHECG
PAQSPKHTEK KLTNQMVHQA WKECYVNQLH HRCSLSNSMT PKKEVSNGLA TWDFTDPGER
APCSCSRLRQ QAKQQQASGS CANPQPGANP SSCPASSAPS LPPPSIPKHK PADKPDKSDK
GPKRVAITPF HHRLSVDQQQ CPDQDPPAGS QLALVPLDPP LDSLPSCKYP KPMSSIRKGP
ESLLHSPVSP LPPTLSPHPR VQDPEAMEAP VGLPHCLEGP PMPPPPEMSE TALYTASLVP
RDAGGGWWKS YRNPRVDKAE FKPSELPCDL LESKLESTGE GTVLKRLYAH THKRFKISEE
RLREHISTLG FLQQPGVEGL TDPGDDPYDF KEGDIEYSFP TSKRLKGPGR DPNRKSKGEE
MNSNNAVPEG KDAMSIFSSA PKSEELAQDE SGAKANPPLT REKDLIVLIS DLENIFGEEE
DELGTTFPNH QQSTKTVAPG AEERPQGIDG RVAVPYPSTV AELQRMFPTP PSLEQHPAFS
PNMTYRDTPS QEPPAPSAGV EHPLSAHANS QLNDFKMEVE DGMSSPKAED ARDFSYVYRV
PSVQPQLGCS MFAPLRALPS QCLPPLKIPE QCYYRPSWAL LPKMEHYCLP AQAPFLRDGY
VNVPSISTLQ DQDYSQMSTC TTSVGTVGGV LPSPATPRFS VPTPRTPRTP RGMGTASGQG
SVKQDGTELS SPASTPSASL PLSSVEPAAC GPALPEAHSL YAILLLSDSV LDVFKDRNFD
SCCICACNTN VKGADVGVYI PDSTREDQYR CMCGFSAIAN RRLAHGAGLF LEDELDIFGR
GSEAGRAAER RLALCRRELP AGATRRGTQE PPMSVLGLIQ EQCSQPITSL ASLHKPAACS
CRSRQGALLQ SWAADRLWAD SIDACVECYN ALVQGLQYVD NATGGKVEQA LVRSTALHSW
PHTNVLDISM LSSQDVVRML LSLQPFLQDA IQKKRTGRTW ENIQHVQGPL TWQQFHKMAG
RGSYGSEESP EPLPIPTLLV GYDRDFLALS PLALPFWEKL LLEPYGGQRD VAYLVLCPNN
DPIINGARAF FQELSAVYES CRLGKHRPLG RVSRDGIVPV GVDEAEKLEE DLVDEWLTGP
WSGQHHEDHL SKLKLYAQTC KQRLAQQLSV LSLDSSLLLL PKPQPSPAPT QPAQSTPSSQ
PTPEADAAAA AASAASAAAS AASAAASAAP ASGSTPTPTS TTSAAQAASA EQGQSETKNV
PNSTLNPNNQ PAESNENNSA ERERIGIPTV ADSADSHVHP PAIVLYMVDP FLCSGTGMGP
GDDEEAEEVE SGSVWLLSLL RCFSDMLSML PENLQPAVVL QVVPCQYLLQ PASGESPLYL
QHLRSLAFSA HSQCRRRLPT QTQIKSLTGF GPAATVESLL KSPENPSSMQ VYSPPFILGP
TRSKQPEAGE VCSDTPARNN VLFVGYCLSH DQRWILVSCT DQQGELLETS IINIDVPNRS
RRPKFSPRKI GLKKVWEWCI SIIQMTAVPW RIVIGRLGRL GHGELKDWSL LLGEHSLHSI
SKQLREACRM CGISAADSPS ILSACLVSME PQGSFVVMPD AVTMGSVFGR STALNLQTSQ
LNTPQDASCT HILVFPTSST TQVAPSSYPT EDNPDDMFGL PFPDELENDI GHDMMFFTGN
LHPSPNTSPV PSPGSPSGMG VGSHFQHTRS QGERLLSREA PEELKQQPLA LGYYVSTAQA
EGLPHWFWAS CPQAQNQCPL FLKASLHHHI SIAQTDELVS SKTSQRSPHP LDSKTTSDVL
RFVLEQYNAL SWLTCNPATQ DRRSCLPVHL VILIQMYNAI LNIL
//
