ID A0A3B1IMQ5_ASTMX Unreviewed; 371 AA.
AC A0A3B1IMQ5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=NSFL1 cofactor p47 {ECO:0000256|ARBA:ARBA00019548};
DE AltName: Full=p97 cofactor p47 {ECO:0000256|ARBA:ARBA00030329};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000031182.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000031182.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Golgi apparatus,
CC Golgi stack {ECO:0000256|ARBA:ARBA00004348}.
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DR RefSeq; XP_007249990.1; XM_007249928.2.
DR AlphaFoldDB; A0A3B1IMQ5; -.
DR STRING; 7994.ENSAMXP00000031182; -.
DR Ensembl; ENSAMXT00000029779.1; ENSAMXP00000031182.1; ENSAMXG00000031552.1.
DR GeneID; 103039398; -.
DR KEGG; amex:103039398; -.
DR CTD; 55968; -.
DR GeneTree; ENSGT00520000055567; -.
DR InParanoid; A0A3B1IMQ5; -.
DR OMA; EHQAFYA; -.
DR OrthoDB; 5483331at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000031552; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR CDD; cd14348; UBA_p47; 1.
DR CDD; cd17162; UBX_UBXN2C; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.420.210; SEP domain; 1.
DR InterPro; IPR036241; NSFL1C_SEP_dom_sf.
DR InterPro; IPR012989; SEP_domain.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR001012; UBX_dom.
DR PANTHER; PTHR23333:SF24; NSFL1 COFACTOR P47; 1.
DR PANTHER; PTHR23333; UBX DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF08059; SEP; 1.
DR Pfam; PF14555; UBA_4; 1.
DR Pfam; PF00789; UBX; 1.
DR SMART; SM00553; SEP; 1.
DR SMART; SM00166; UBX; 1.
DR SUPFAM; SSF102848; NSFL1 (p97 ATPase) cofactor p47, SEP domain; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51399; SEP; 1.
DR PROSITE; PS50033; UBX; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 178..243
FT /note="SEP"
FT /evidence="ECO:0000259|PROSITE:PS51399"
FT DOMAIN 292..369
FT /note="UBX"
FT /evidence="ECO:0000259|PROSITE:PS50033"
FT REGION 49..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 371 AA; 40553 MW; 089CCFD49F511849 CRC64;
MAQREEAVSE FVAVTDVDEE RARFFLESAG WDLQLALASF FEDGAEDDIV TLPQSESGSV
SRSTGPSEHR VTSFRDLRHE DEDESDEEGQ RFFAGGSERS GQQIVGPPKK KSTNEVVEDL
FKGAKEHGAV PVDKAGRGPG ESSKSKPFVG GGYRLGAAPE EESAYVAGER RTSGSSQDVH
VVLKLWKTGF SLDDGDLRNY SDPGNALFLE SIRRGEIPLE LRQRSRGGQV NLDMEDHRDE
DFSRPRPAFR AFGGEGQKLG SATPELVSAP RMGAQEQAAS EAQASASISV DDSQPVTQIQ
IRLADGGRLV QKFNHTHRVS DVRQFVVSAR PAMAAAEFVL MTTFPNKELT DESQTLKEAN
LLNAVIVQRL K
//
