ID A0A3B1INN8_ASTMX Unreviewed; 644 AA.
AC A0A3B1INN8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=NACHT domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000031562.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000031562.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1INN8; -.
DR Ensembl; ENSAMXT00000038192.1; ENSAMXP00000031562.1; ENSAMXG00000039704.1.
DR GeneTree; ENSGT01100000263476; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000039704; Expressed in olfactory epithelium and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 6..122
FT /note="NACHT"
FT /evidence="ECO:0000259|Pfam:PF05729"
FT DOMAIN 206..264
FT /note="NOD2 winged helix"
FT /evidence="ECO:0000259|Pfam:PF17779"
FT DOMAIN 266..395
FT /note="NACHT LRR and PYD"
FT /evidence="ECO:0000259|Pfam:PF17776"
SQ SEQUENCE 644 AA; 73270 MW; B3187A82617A7BC7 CRC64;
MKEKKLSLVN LLQDFFPETQ DLKPRHYKSY KIMFIFDGLD ECRLPLDFQN NENLVNIEEQ
TSVEVLLTNL IKGNLLPSAL LWITSRPAAA NQIPPECFDQ VTEVRGFSDP QKQEYFSKRI
RDQDLANKVF THIRSSRSLH IMCHIPVFCW ITATVLERML SEAESGEIPK TLTQMFTHFL
IFQIKLKNQK YSGKSDTDPQ QTRTSILALG KLAFQQLEKG NLIFYEEDLI ESGINIREVS
VYSGVCTQIF REELELHLGK VFSFVHLSVQ EFLAALYAFL NRKIPKEQST ETQTGKLLKF
FSKSTMTDFL SSAIDRALQS ESGHLDLFLR FLLGLSLQSN QTLLGVLLTP TQRISHSNKT
VQYIKMKIEE NSSPEKSINL FHCLNELNDH SLVQEVQKYL SGGGEGRLQQ SRLSPAQWSA
LAFVLVNSEE ELEEFNLSKY DASEECLLRL LPVVKISRRA VLASCNLGVK TCENLESVLN
LENSFLKELD LSNNDLQDSG VELLSAGLKR SHCKLQILRL SGCMITEKGC CSLASALISN
PSHLKELDLT YNHPGESGVK LLSDRLEDPH CKLEKLGVEH GGKIRIKPGL KKCKLHTHYI
QTLHTHTHTL YTNNTHTKYN TTHTHTKLTL HTHTLNITLH THTH
//
