ID A0A3B1IPZ4_ASTMX Unreviewed; 730 AA.
AC A0A3B1IPZ4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000031279.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000031279.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1IPZ4; -.
DR STRING; 7994.ENSAMXP00000031279; -.
DR Ensembl; ENSAMXT00000049637.1; ENSAMXP00000031279.1; ENSAMXG00000033415.1.
DR GeneTree; ENSGT01040000240375; -.
DR InParanoid; A0A3B1IPZ4; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000033415; Expressed in ovary and 3 other cell types or tissues.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR46670; ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46670:SF3; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 497..730
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 730 AA; 79772 MW; B80C288586748F4D CRC64;
MCFQIPTLIS CNTRRHRHQG RNRNPSNLLY PPSSLSSQVL VHGGLWNCHS AVLKADFITA
LASAQSLDFL ALTETWITPE NSATPAALSS AFAFSHSPWP TGRGGGTGLL LSRKWSFTVL
SFLHLDISSF EFHAVTISFP VKLHIIVLYR PPGPLGNFID ELDTLLSGLP VESSLILLGD
FNLPSEKLQS SCLLPLLSSF SLSLNLSAPT HRAGNTLDLV FSRPAPALDL TVTPLDFSDH
HFLSFTLSLP ALPTNTTSSI STTHCNLRAI SPSSLASTIL TTLPNPDSFS SLPLETATNT
FLSSITSSIN TLSPLTSRPA KSSPATPWLS DVLRNNRREL RLAERKWKKS QQYSDLCSYQ
SLLSRFSTEV TAAKSSFYKR KLEESASDPR KLFTIFSPLL NPPTPQPPTT LSPDDFVNFF
EEIVANIRQS FPPASTLHTK LCLPHSTSLS HFSLLSTDEI LHLLHSNNPT TCPLDPLPSS
LFQTIAPDLL PFITHIINTS SGHVPSTFKT ARVVPILKKS TLDSLDVGNY RPVSLLSFLS
KVLERAVYNQ LSLFLTQNNL QDPNQSGFKP AHSTETALIA VTEKLHAAKA TNLSSVLILL
DLSAAFDTVN HSTLLSILTS LGIIGSAWQW FASYLEDRSY QVTWQGATSA PCRLSTGVPQ
GSVLGPLLFS LYTRSLGEII SSHGFSYHCY ADDTQLILSF PPSDTQVSSR ISACLNVDEF
SSPKTQPQQD
//
