ID A0A3B1ISQ7_ASTMX Unreviewed; 412 AA.
AC A0A3B1ISQ7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Sprouty related EVH1 domain containing 1 {ECO:0000313|Ensembl:ENSAMXP00000032555.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000032555.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000032555.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007257446.1; XM_007257384.2.
DR AlphaFoldDB; A0A3B1ISQ7; -.
DR STRING; 7994.ENSAMXP00000032555; -.
DR Ensembl; ENSAMXT00000031465.1; ENSAMXP00000032555.1; ENSAMXG00000030050.1.
DR GeneID; 103044678; -.
DR KEGG; amex:103044678; -.
DR CTD; 161742; -.
DR GeneTree; ENSGT00940000159180; -.
DR InParanoid; A0A3B1ISQ7; -.
DR OrthoDB; 3031266at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000030050; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd10574; EVH1_SPRED-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR023337; KBD.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041937; SPRE_EVH1.
DR InterPro; IPR007875; Sprouty.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR11202:SF18; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF05210; Sprouty; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51488; KBD; 1.
DR PROSITE; PS51227; SPR; 1.
DR PROSITE; PS50229; WH1; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 6..125
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 200..254
FT /note="KBD"
FT /evidence="ECO:0000259|PROSITE:PS51488"
FT REGION 258..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 412 AA; 46705 MW; 6BCAD0248F962918 CRC64;
MSEESANPNN DDSYARVRAV VMTRDDSSGG WLPLGGGGLS CVSVHKVSRP DTDSSSGVDF
LIQGERLKDK SVVLECNIKR DLVYNKVTPI FHHWRIDNKK FGLTFQSPAD ARAFDRGIRR
AMEDIKQGCP VYSDSDTPED GLQVNQDPPS ICTPMREPFS PHGGVVSTEP FRGCYVRAQP
FDEFPSPNRR YLPPQVSFNT TRHVSFHMDD EEVVRINPRK DVLIRGYEDY RHPVMWKQDM
ERDDGDFSTT FSKLDNKKSE YLFPEGPETH PGGKDSIKTQ QPSPLLKSKK SRRRREDGER
SRCIYCREMF NHEDNWRGQC QDAPDPIKQC IYKVSCMLCA ESMLYHCMSD SEGDFSDPCS
CDTSEEQFCL RWLALLGLSL IAPCMCCYPP LRACHHCGEA CHCCGGKHKA AG
//
