ID A0A3B1ISR7_ASTMX Unreviewed; 713 AA.
AC A0A3B1ISR7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Tripartite motif-containing protein 65-like {ECO:0000313|Ensembl:ENSAMXP00000033047.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000033047.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000033047.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1ISR7; -.
DR STRING; 7994.ENSAMXP00000033047; -.
DR Ensembl; ENSAMXT00000038671.1; ENSAMXP00000033047.1; ENSAMXG00000037679.1.
DR GeneTree; ENSGT00940000154294; -.
DR InParanoid; A0A3B1ISR7; -.
DR OrthoDB; 4210900at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000037679; Expressed in ovary and 11 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR CDD; cd19776; Bbox2_TRIM25_C-IV; 1.
DR Gene3D; 2.60.120.920; -; 2.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR PANTHER; PTHR25465:SF31; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 99..140
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 433..706
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 713 AA; 80412 MW; 217E751184611754 CRC64;
MSSRSSSFSS TQKNKRSLSI LPNFRFVRKG RESSRARPLL LLLLFAEARA QLGMRTGGVC
LVLSSRVLHG DFHKHTHTAE MASKPSIIPL LLQEDELMCP ICRALIRNPV TTPCGHSFCM
PCIQQHWARS SLPWFCPHCR RSFICKPVLQ PSTVLCSIME NVAKVWPEPE PCTEPAPGIT
CDVCEDGRQL PADKTCVTCL ASFCRVHLMP HTGSRALKKH CLCAPVSNLK ELQCEKHGRA
LELFCRGHRV PVCWQCMPKH RRCSVRAVEE IRREWKASID PVANEAKDRA DATDRALESL
DTLSEGVVAS AEKMKEDVEL CFEALRETIG RVQDKVLTFI DAERTCVLQR IQEHQKILNS
HLLAVSETVN QLNKCRTNDS YFNFSQPLPL VPPEISPLQE ADVQMDGRAV ERIILDLQQI
QNHLELNHLE SQLCSNLKKH ATNTLQDKDS CGVTFDPTTA SASVLLSDDS SSLTVEHSGL
LAWKDHQVNL ELNFRVMCSQ NFTRGQHYWE VMPPRDLRRN WAVGVTYKNC QDCYQGSGQD
QRSWYVIWRN AGKKTSDNCE KNENTDTCKG AEDAILKRTL RKTREDNVLH AAEHGGDAPK
RTKEKVVKDK VQGHVTATRK KENNKVITGF FASHNQNTHL ISMSPPGKIG VHLDCDRGWL
SFFTVSGSRV RLCYRFQTLS SKPLRPAVWL RDPEETTAIS TRGASDSEEQ MGS
//
