ID A0A3B1ISY4_ASTMX Unreviewed; 652 AA.
AC A0A3B1ISY4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Phosphatidylinositol binding clathrin assembly protein {ECO:0000313|Ensembl:ENSAMXP00000032269.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000032269.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000032269.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PICALM/SNAP91 family.
CC {ECO:0000256|ARBA:ARBA00008011}.
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DR AlphaFoldDB; A0A3B1ISY4; -.
DR Ensembl; ENSAMXT00000056737.1; ENSAMXP00000032269.1; ENSAMXG00000003309.2.
DR GeneTree; ENSGT00950000183068; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000003309; Expressed in intestine and 14 other cell types or tissues.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:InterPro.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR CDD; cd16985; ANTH_N_AP180; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 1.20.58.150; ANTH domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR014712; ANTH_dom_sf.
DR InterPro; IPR045192; AP180-like.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR PANTHER; PTHR22951; CLATHRIN ASSEMBLY PROTEIN; 1.
DR PANTHER; PTHR22951:SF16; PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN; 1.
DR Pfam; PF07651; ANTH; 1.
DR SMART; SM00273; ENTH; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50942; ENTH; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 14..145
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT REGION 343..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 70444 MW; 388E46D2A4EB7E3C CRC64;
MSGQSITDRI TAAQHSVTGS AVSKTVCKAT THEVMGPKKK HLDYLIQCTN EMNVNIPQLA
DTLFERTTST SWVVVFKSLI TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM
STFIRRSSRY LNEKAVSYRQ VAFDFTKVKR GSDGVMRTMN TEKLLKTLPI VQNQMDSLLD
FNVNANELTN GVINAAFMLL FKDAIRLFAA YNEGIINLLE KYFDMKKAQC KEGLDIYKKF
LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKV KDSTAASRAS
TLSNAVSSLA NTGISFTKVD EREKQAALDE EQARLKALKE QRLKELSKKP STSSTTAASP
VSTATGTIST APAIDLFSTP SSTSSTTKVP SDLLDLQPAF QPSLPLPTAL PVTNTWGDSF
CSPAPYSNTP LFHSEPSNVA GLFGGFSASP VPQPASSSSL NVDFDSVFGN KSTANNTDAA
DDVLGGILKP TVASPNQGLP PSIHQPNKLV SDDLDSSLAN LVGNLGIGNG TAKNDIHWSQ
PGEKKLTGGT NWQPKNAPTT TWNPATMAPS VMAFPATTPT GMMGYPMPPQ MAPMAMMTQP
TMMYTQPVMR PPNPFGPVSG AQPSAASSPS SQSPLRPPGQ DPFAQLSLKD FL
//
