ID A0A3B1ITW6_ASTMX Unreviewed; 1775 AA.
AC A0A3B1ITW6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000033378.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000033378.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR Ensembl; ENSAMXT00000029768.1; ENSAMXP00000033378.1; ENSAMXG00000004617.2.
DR GeneTree; ENSGT00940000156263; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF23; SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 91..109
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 121..143
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 188..207
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 219..240
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 365..381
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 550..568
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 580..598
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 651..671
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 730..756
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 997..1015
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1036..1055
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1111..1137
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1234..1260
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1318..1336
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1348..1366
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1378..1398
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1435..1463
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1538..1561
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 128..369
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 403..513
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 549..762
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 770..990
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 995..1269
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1317..1571
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 28..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1721..1775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1721..1744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1746..1775
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1775 AA; 202507 MW; 36C06B806DAA70F6 CRC64;
MAAPLLAPPG PDSFKYFTRE SLVNIEKRIA EEKAKPPPKP DSSYRDDDDE NKPKPNSDLE
AGKGLPFIYG DIPVGDGGDT TFIVLNKGKT IFRFSATPSL YMISPFNIFR RIAIKILIHS
YPFLSCFMII MCTILTNCVF MTFSNPPEWS KQVEYTFTGI YTFESAVKII ARGFCIDDFT
FLRDPWNWLD FMVISMAYVT EFVDLGNVSA LRTFRVLRAL KTISVIPGLK TIVGALIQSV
KKLSDVMILT VFCLSVFALI GLQLFMGNLR QKCVIWPINI TESYQGNSSR FDWNEYIMNE
TNFYFLPGTL DALLCGNSSD SGRCPEGYTC MKAGRNPNYG YTSFDSFGWA FLALFRLMTQ
DFWENLYQLV GVMFFTILLI WKTLKHKQQR KFLTVCCFAL LQSLLSIPGS PFLSRHNSKS
SIFSFKGRCR DAGSENEFAD DEHSTVEECE ERRGSLFSPY RRSSYSGYHG KRNSTVDCNG
VVSLIGPGPG GRLLPEVIID KAASDDKLEE SQRKCPPCWY KFANIFLIWE CCPAWLKIKE
IVNLIVMDPF VDLAITICIV LNTLFMAMEH YPMTPQFEHV LSVGNLVFTG IFTAEMFAKL
VAMDPYYYFQ EGWNIFDGLS VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS VGALGNLTLV
LAIIVFIFAV VGMQLFGKSY KDCVCKIAQD CELPRWHMND FFHSFLIVFR VLCGEWIETM
WDCMEVAGQA MCLIVFMMVM VIGNLVVLNL FLALLLSSFS ADNLAATDDD GEMNNLQISV
NRIKTGIAWF KAKVRQLVAI ILKRKVTDEA KPLDELYDRK LNCIANHTGV DINRDLDYQK
NGNGTTSGIG SSVGKYMIDE DHMSFIHNPN LTVCVPIAVG ESDFENLNTE DFSSESEVLV
CLWESITPDS FMPFLYVGMI NTLDDSSSSE GSTIDIKPEV EEAVVVEAVE EYLDPEACWT
EACIARYKCC DVPITEGWGK NWWYLRKTCY LIVEHNWFET LIIFMILLSS GALAFEDVYI
EQRKTIRIIL EYADRVFTYI FILEMLLKWV AYGFVKYFTN AWCWLDFFIV DVSLSLSNAL
GYSDLGPIKS LRTLRALRPL RALSRFEGMR VVVNALVGAI PSIMNVLLVC LIFWLIFSIM
GVNLFAGKYY YCYNATAEEY FDPDEVNNKT QCFELINQNF TEVRWKNVKI NFDNVGAGYL
ALLQVATFKG WMDIMYAAVD SRRVEDQPMY EDNIYMYIYF VIFIIFGSFF TLNLFIGVII
DNFNQQKKKI SQDIFMTEEQ KKYYNAMKKL GSKKPQKPIP RPQNKIQGMV FDFVTQQVFD
ISIMILICLN MVTMMVETDD QSDETENILY WVNFIFIVVF TSEFVLKLFA LRHYYFTNGW
NIFDCVVVIL SIVGMFLADL IEKYFVSPTL FRVIRLARIG RILRLIKGAK GIRTLLFALM
MSLPALFNIG LLLFLVMFIF SIFGMSNFAY VKREAGIDDM YNFETFGNSM ICLFMITTSA
GWDGLLAPIL NYAPDCDPNK ENPGTTVKGN CGNPSVGIFF FVMYIIVSFL IVVNMYIAII
LENFSVATEE SADPLCEDDF ESFYEIWEKF DPTASQFISF AKLSDFADTL EHPLRVPKPN
TIELIAMDLP MVSGDRIHCL DILFAFTKRV LGDSGDLDMM RQQMEERFIA ANPSKVSFEP
ITTTMRRKQE HMSAQVIQRA YRAHLVRQGF ICKRFLGSSR LENGGTNQDK KEGTPSTASL
PSYDSVTKPE KEKLDDSESK GKKGKNQKDV KESKC
//
