ID A0A3B1IV28_ASTMX Unreviewed; 679 AA.
AC A0A3B1IV28;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=SRCR domain-containing protein {ECO:0000259|PROSITE:PS50287};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000033556.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000033556.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR AlphaFoldDB; A0A3B1IV28; -.
DR Ensembl; ENSAMXT00000030085.1; ENSAMXP00000033556.1; ENSAMXG00000039229.1.
DR GeneTree; ENSGT00950000183145; -.
DR InParanoid; A0A3B1IV28; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000039229; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR Gene3D; 3.10.250.10; SRCR-like domain; 10.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR19331:SF22; DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN; 1.
DR PANTHER; PTHR19331; SCAVENGER RECEPTOR DOMAIN-CONTAINING; 1.
DR Pfam; PF00530; SRCR; 4.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 5.
DR SUPFAM; SSF56487; SRCR-like; 10.
DR PROSITE; PS50287; SRCR_2; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 37..172
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 188..296
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 312..420
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 436..544
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 560..669
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DISULFID 638..648
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 679 AA; 75691 MW; DCCB4E6B29B104B0 CRC64;
MFFFFFFFFF FFFFFLLLYC IIVAYCFSSV NSGHTQARLM NGSDSCSGRV ELQYLSEWGT
VCDVSWDMRA ASVLCAQVEC EGEVEVFFRQ DWRRVLLDSW SESEASVVCR QLQCGVALSA
PVPVPARFGS GTGPIWLNEV ECEGEVEVFF RQDWRRVLLD SWSESEASVV CRQLQCGVAL
SAPVPVPARF GSGTGPIWLN EVECEGEVEV FFRQDWRRVL LDSWSESEAS VVCRQLQCGV
ALSAPVPVPA RFGSGTGPIW LNEVECEGEV EVFFRQDWRR VLLDSWSESE ASVVCRQLQC
GVALSAPVPV PARFGSGTGP IWLNEVECEG EVEVFFRQDW RRVLLDSWSE SEASVVCRQL
QCGVALSAPV PVPARFGSGT GPIWLNEVEC EGEVEVFFRQ DWRRVLLDSW SESEASVVCR
QLQCGVALSA PVPVPARFGS GTGPIWLNEV ECEGEVEVFF RQDWRRVLLD SWSESEASVV
CRQLQCGVAL SAPVPVPARF GSGTGPIWLN EVECEGEVEV FFRQDWRRVL LDSWSESEAS
VVCRQLQCGV ALSAPVPVPA RFGSGTGPIW LNEVECEGEV EVFFRQDWRR VLLDSWSESE
ASVVCRQLQC GVALSAPVPV PARFGSGTGP IWLNEVECEG NEASLWNCRY QLCGEDECGH
KDDVGVVCSG TSYLELLSL
//
