ID A0A3B1IVJ6_ASTMX Unreviewed; 1337 AA.
AC A0A3B1IVJ6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Synaptic Ras GTPase activating protein 1b {ECO:0000313|Ensembl:ENSAMXP00000033109.1};
GN Name=SYNGAP1 {ECO:0000313|Ensembl:ENSAMXP00000033109.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000033109.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000033109.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSAMXT00000038228.1; ENSAMXP00000033109.1; ENSAMXG00000024615.2.
DR GeneTree; ENSGT00940000158438; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000024615; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR PANTHER; PTHR10194:SF25; RAS_RAP GTPASE-ACTIVATING PROTEIN SYNGAP; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 2.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 206..240
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 231..349
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 416..608
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 703..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1220..1279
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1018..1091
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1337 AA; 150372 MW; D3173C3AA4794BF2 CRC64;
MLTHTDHTDA RYAVPPSYRS QASYAAPSYE QPGWNPRMIS GNQIYMLDQE EVHPLLMRER
RSESHRNKLL RRTVSVPVEG RHHPEMDHAR LRRKSIATGR QPSMETPPIA PPQPFRQSSF
LSRRLKGSIK RAKSQPKLDR TSSFRHMILP RFRSADQDRT RLMQSFKESH SHESLLSPSS
AAEALDLTLD EDAIIKPVHS SILGQEYCFE VTTASGTKCF ACRSAAERDK WIENLQRAVK
PNKDNSRRVD NVLKLWIIEA RELPPKKRYY CELCLDDMLY ARTTSKPRTD TVFWGEHFEF
NNLPAVRNLR LHLYKETDKK RRKEKSTYLG LVSIPISSIT GRQFVEQWYP VIQPSVLAKG
GGVGGGKIIN ASLRLKSRYQ TMSILPMELY KEFAEYVTNN YRTLCAVLEP LLSVKSKEEV
ACALVHILQS TGKAKDFLSD MAMCEVDRFI DREHLIFREN TLATKAIEEY LKLIGHKYLK
DALGDFIRAL YESEENCEVD PMRTPPSVLA DHQANLRMCC ELALCKIVNS HCVFPRELKE
VFASWRVRCA ERGREDIADR LISGSLFLRF LCPAVMSPSL FNLTQEYPDE QTSRTLTLIA
KVMQNLANFS KFGSKEEYMC FMNEFLEMEW GSMQQFLYEI SNLDSVSNAV AFEGYIDLGR
ELSILHSLLW EVMAQLSKDA IIKLGPLPRL LNDISMALRN PHLQRQPSHQ TDRQPPERQT
DRLLSRPSFN RGISSEFQNV MMRDLNSSID ITRLPSPTSA MSSGGVPPSR AGMGGYADRD
HPHRASSKDV FYVTRPPLAR SSPAYCTSSS DITDPDPKDS RMNSVSNLQS VGDMLNSSQA
SLAGLGSFGG GLGGLGGGLG GQLRAGGGRM SAGSGGSSMS GGLRLSQLSQ MGTTTDSLSQ
QQQQQAAALR YPLSFQNPLF HMAADGPQLH HQHSRAQPAA PLLLTPEPDP SHPAYLPQFA
RGGFSRSEDL STLRPGPHLG QPSIIHSHSY SDDYSRHNQD YGRRQISMHM QDNLQQQQMM
GMASQTGTSH SSLASPPSTV QPVRQSSMAP PPTQRMKSQT SHQLSVSSAA GATPPSKTRP
QSGNLLQSPE SGFGGRQPGP RQQLSVKDNT APGLPHQQSS TRESQGSQGS QGGTPQSTQQ
SVSHQDRQHS QQHLLKPSIS KQGSSPNTLN PPTPASERTV AWVSNMPHLS ADIESSRIDR
EEFKLKEYSK SMDESRLDRV REYEEEIHSL KERLMMSHRK LEEYERRLLT QEQQTNKILL
QYQSRLDDSE RRLRQQQLEK DSQIKGIIDR LMAVEDELRA GAASEHKARI FADQGRRQSI
LVQPRLAPVP PRMHRPH
//
